Clinical Significance Of Prognosis Of Liver Cirrhosis With Serum Neutrophil/Lymphocyte Ratio

ObjectiveIn China,cirrhosis is a common disease in the digestive system.Objective,accurate,inexpensive and reproducible scoring system is important for predicting cirrhosis.Various clinical and laboratory indicators include serum albumin,hyponatremia,creatinine,prothrombin time,cirrhosis complications,etiology,and inflammatory markers have been proposed as predictors.The CTP and MELD scores are well established and commonly used scoring systems in cirrhosis prognosis and mortality predictions.To investigate the clinical significance of neutrophil / lymphocyte ratio(NLR)in predicting the prognosis of liver cirrhosis.MethodsA total of 163 patients with liver cirrhosis were diagnosed as liver function,blood routine,creatinine and international standard(INR),and their NLR,end-stage liver disease model(MELD)score,Child-Pugh(CTP)score were analyzed.And CTP score,MELD score,survival prognosis.Results: The NLR and CTP scores(r = 0.291,P = 0.002),MELD score(r = 0.271)weresignificantly higher than those in the death group(P <0.05),and the difference was statistically significant(P <0.05),P = 0.004).The unconditional logistic regression analysis showed that NLR was an independent risk factor for death in patients with liver cirrhosis(P <0.1).ResultThe basic characteristics,age,Child-Pugh score,total white blood cell count,neutrophil count,lymphocyte count,total bilirubin value,serum albumin value,serum creatinine and serum creatinine were analyzed in 163 patients with cirrhosis and survival group(P <0.05).There were no significant differences between the two groups(P <0.05)NLR,serum albumin concentration,MELD score,CTP score and prothrombinin INR value were significantly different(P <0.05).The NLR value of death group was significantly higher than that of survival group.NLR was significantly higher in decompensated cirrhosis and decompensated cirrhosis than in decompensated cirrhosis(P= 0.03).The relationship between NLR and CTP score was analyzed by Spearman correlation analysis(r = 0.357,P <0.01): NLR was positively correlated with CTP score.The relationship between NLR and MELD score was analyzed by Spearman correlation analysis(r = 0.175,P = 0.025): NLR was positively correlated with MELD score.By unconditional logistic regression analysis,NLR elevation was an independent risk factor for short-term death of cirrhosis(OR = 0.603,P =0.001 <0.1).The mortality rate for the 24-month mortality was 3.61(AUC= 0.8)for 21.4% of patients undergoing cirrhosis during follow-up(22.8 ± 4.4 months of follow-up).Conclusion1.The NLR was significantly higher in the death group than in the survival group.2.Patients with decompensated liver cirrhosis were significantly higher than those in patients with decompensated cirrhosis.3.There was a positive correlation between NLR and CTP scores and MELD scores in patients with liver cirrhosis.4.Elevated NLR is an independent risk factor for 24 months of death in cirrhotic patients.5.The NLR predicts a higher degree of specificity and sensitivity to death in patients with cirrhosis.