Variation Tendency Of The Level Of Fasting Plasma Glucose In Patients With Decompensated Liver Cirrhosis

Objective1. To observe the variation tendency of the level of fasting plasma glucose in patients with decompensated liver cirrhosis both in a death group and a survival group.2. To observe the relativity between Model for End-stage Liver Disease (MELD) score and the level of fasting plasma glucose in patients with decompensated liver cirrhosis both in a death group and a survival group.MethodsMedical data of 120 cases of decompensated liver cirrhosis was collected. Those being dead till the beginning of this research were grouped into the death group, those being still alive till the beginning of this research were grouped into the survival one. By the way of retrospective study, and based on their clinical data, the level of fasting plasma glucose, Child-Turcotte-Pugh (CTP) score and MELD score were recorded at 18,12,6 months before any time point within six months early just right than death in the death group and at18,12,6 months before any time point early than March 2009 in the survival group.Results1. The level of fasting plasma glucose in the death group of patients with decompensated liver cirrhosis had a gradual downtrend along with time within 18 months before death, whereas the level of fasting plasma glucose in the survival group of patients with decompensated liver cirrhosis had a tendency of fluctuating and increasing while surviving (F=17.387, P=0.000). The difference of trends of the level of fasting plasma glucose between two groups was significant (F=29.650, P=0.000).2. Significant negative correlation was observed between MELD score and the level of fasting plasma glucose in the death group of patients with decompensated liver cirrhosis, as the MELD score added one score, the level of fasting plasma glucose decreased 0.08 mmol/L. No significant correlation was observed between MELD score and the level of fasting plasma glucose in the survival group of patients with decompensated liver cirrhosis.3. The average level of fasting plasma glucose at 6 months before death in the death group of patients with decompensated liver cirrhosis reached 4.36mmol/LConclusions1. Patients with decompensated liver cirrhosis had a gradual downtrend in the level of fasting plasma glucose within 18 months before death.2. Significant negative correlation was observed between MELD score and the level of fasting plasma glucose in patients with decompensated liver cirrhosis, as the MELD score added one score, the level of fasting plasma glucose decreased 0.08 mmol/L.3. Patients with decompensated liver cirrhosis probably had bad short-term (6 months) prognoses if the average level of fasting plasma glucose droped to 4.36mmol/L and CTP went up to grade C gradually.