The Association Between Platelet To Lymphocyte Ratio And Takayasu Arteritis Disease Activity

Objective:Takayasu arteritis(TA)is a chronic,progressive,granulomatous inflammatory disease that can cause the ischemic and infarction of the involved organs,lead to organ failure,bleeding or shock eventually,this will seriously threaten the life of patients.Recently,a larger of studies have shown that Platelet to lymphocyte ratio(PLR)is associated with various diseases such as therioma,coronary artery disease and autoimmune disease.Inflammation may be one of the factors associated with diseases and PLR.However,there is no report about the association between PLR and TA.Therefore,our study focus on the association between PLR and TA,and analyze the predictive value of PLR to activity of TA.Methods:This retrospective study involved 105 TA patients who were first time diagnosed in the First Affiliated Hospital of Xinjiang Medical University from 2010 to 2015.TA patients were divided into Active TA group(a-TA)and Non active TA(na-TA)group according to National Institutes of Health(NIH)activity criteria,blood routine and immune index were tested in the study.Results:PLR were higher in a-TA patients compared with na-TA(145.4 ±53.25 vs.104.4 ± 34.45,P<0.001).PLR was negatively correlated with lymphocyte count in patients with a-TA,and positively correlated with C reactive protein(CRP),platelet count,hemoglobin and neutrophil to lymphocyte ratio(NLR),NIH activity score.Stepwise logistic regression analysis showed that PLR was associated with a-TA independently of erythrocyte sedimentation rate(ESR)and CRP.When Receiver operating characteristic(ROC)curves were used to identify the performance of PLR in assessing a-TA,the area under the curve was 0.763(95% CI: 0.644-0.842,P<0.001)with the sensitivity and specificity of 82.6% and 55.5%,respectively.Conclusions: Our study suggests that increased PLR is associated with TA patients with active disease,and is correlated with CRP in active TA patients.These results can help clinical practice on assessing disease activity and reflect active inflammation in patients with TA.