| Objective To explore the regularity of the treatment of ancient and modern reflux esophagitis and the clinical randomized controlled study,and to explore the regularity of the treatment of sputum,noisy and modern treatment of hot and humid refractory esophagitis prescription.And to observe the clinical effect of adding and reducing decoction to treat hot and humid refractory esophagitis and to explore its possible mechanism.Methods The first part of the theoretical study:through the collection,collation,induction of relevant literature,and the ancient 149 treatment of spit acid,noisy and modern treatment of 50 cases of hot and humid refractory esophagitis prescription drug frequency,frequency statistics and association rules.The second part of the clinical study:60 cases of hot and humid refractory esophagitis patients were randomly divided into treatment group and control group of 30 cases.The two groups were treated with omeprazole as the base treatment.The treatment group was treated with addition and subtraction,and the control group was treated with mosapride tablets for 8 weeks.To observe the clinical symptoms before and after treatment,endoscopic esophageal inflammation and bile reflux,plasma motilin and prostaglandin E2 levels.Results(1)reflux esophagitis should be included in traditional Chinese medicine spit acid,noisy areas,traditional Chinese medicine or integrated traditional Chinese and Western medicine have a better effect.(2)the ancient 149 prescription research showed that:the highest frequency of tonic drugs(17.64%),followed by qi medicine(15.70%),dampness medicine(15.61%),heat-clearing medicine(12.93%),warm-lian medicine(11.36%),Huatan cough and asthma drugs(8.86%),the cumulative frequency of 82.10%,is the treatment of "noisy","spit acid" of the main drugs.The use of frequency greater than 8 commonly used 31 drugs(more than 30 drugs can be composed of two Shuang Er Chen and Zuo Jin Wan).The highest frequency is dried tangerine peel(8.49%);Drug mildness(51.49%)was significantly higher than that in plain(19.46%)and cold(12.78%).Sesame flavor(37.03%),bitter(31.09%)taste the majority,followed by sweet(19.91%)taste;Meridian through the spleen(27.97%),the majority of the stomach(21.90%),followed by the lung(13.88%),heart(10.72%);The highest degree of support for the combination of Poria-tangerine peel(30.87%),triple drug for the Pinellia Coptis-dried tangerine peel(3)Modern 52 prescription research shows:The highest frequency of heat medicine(19.10%),followed by tonic drugs(15.45%),Huatanzhike antihypertensive drugs(14.06%),qi medicine(12.15%),dampness medicine(10.07%),solution drugs(7.99%),The cumulative frequency of 78.82%,is the treatment of hot and humid refractory esophagitis in the main drug.The use of frequency is greater than 4 commonly used 32 taste drugs(frequency greater than 20 drugs can be composed of Zuoj in pill and Xiao Chai Hu plus Poria soup),The highest frequency was berberine(6.60%).The mildness(29.14%)and cold(28.04%)were the highest(16.34%),slightly cold(12.28%).Taste to bitterness(40.30%)mostly,followed by Xin(26.27%),sweet(15.41%)taste;Meridian(21.78%),Stomach(20.80%)mostly,followed by the lung(14.78%),liver by(10.78%);The highest degree of support for the combination of berberine-Evodia(48.08%),triple drug for the Evodia Pinellia-Coptis.(4)Clinical studies showed that:There were significant differences in endoscopic scores between the two groups before and after treatment(P<0.05).The curative effect of endoscopic esophageal inflammation in the two groups was better than that in the control group(P<0.05).There were no differences in the scores of the two groups before treatment,and the scores of the two groups were different after treatment.The treatment group was better than the control group(P<0.05).The difference between the two groups was better than that of the control group(P<0.05).The levels of plasma motilin and prostaglandin E2 in the treatment group were significantly higher than those in the control group(P<0.01).The rate of bile disappearance was lower in the treatment group than that in the control group(P<0.05).Conclusion 1)ancient treatment of spit acid,noisy prescription mainly Xin Wen,bitter temperature,to the spleen,stomach,with gasification wet,spleen and stomach effect of drug compatibility group,reflecting the "dampness" and "tonic" Of the main treatment;modern treatment of hot and humid resistance in the type of reflux esophagitis prescription mainly bitter temperature,bitter cold,spleen,stomach,with heat and acid,dampness phlegm,liver and stomach effect of drug compatibility group,Reflecting the "heat" and "transfer liver" the main law.(2)addition and subtraction even Puyin prescription,according to the ancient treatment of spit acid,noisy and modern treatment of hot and humid in the resistance type of reflux esophagitis prescription medication is basically the same,for the clinical treatment of hot and humid resistant reflux esophagitis of the effective prescription,its mechanism may be associated with increased gastric motility,reduce bile reflux,regulate gastrointestinal hormones and so on. |
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