| Objectives: 1. To investigate the personality traits in patients with generalized anxiety disorder. 2. To investigate patients with generalized anxiety disorder after heart rate variability biofeedback training and the changes of intermediate frequency domain, time domain, heart rate, and the level relief of anxiety symptoms. 3. The relationship among the baseline of heart rate variability with hamilton anxiety scale,the score of eysenck personality questionnaire, heart rate and state trait anxiety inventory.Methods:?The study was case-control study, 87 patients were recruited, on the basis of taking 2 capsules of shuganjieyu twice a day and 1 pill of compound diazepam once a day. Eysenck personality questionnaire were assessed in patients.?The second study, the study adopted imported from German Biosign company heart rate variability biofeedback scanning analyzer (HRV -Scanner Professional),determination of the intervention group of 47 patients with generalized anxiety disorder and 40 patients in the control group in patients with generalized anxiety disorder of heart rate variability (HRV), then treated the intervention group with heart rate variability biofeedback training for 6 weeks, HRV data have been collected before and after the experiment in all patients. To assess the symptoms in patients with generalized anxiety disorder and observe the change of anxiety symptoms using Hamilton anxiety scale (HAMA) scale and state trait anxiety inventory (STAI) score quantitative. ?The third study: to explore the correlation between state trait anxiety inventory (STAI), the personality of each dimension, heart rate and heart rate variability in all patients.Results: The first study? the analysis of four dimensions E, P, N, L in eysenck personality questionnaire in patients and healthy controls showed that N scores were significantly higher than normal people[(16.66±3.78)vs(11.6±4.8),p<0.01],which demonstrated patients with generalized anxiety disorder have neurotic personality traits. The second study ?4 patients dropped during this experiment. HRV and heart rate of the intervention group and the control group in patients with generalized anxiety disorder before and after 6 weeks using the two comparative analysis, the result showed that LF component in HRV frequency domain index significantly reduced [(2.15±0.43)ms2 vs(1.99±0.43)ms2,p=0.017] in the intervention group, it's statistically significant, P < 0.01, frequency domain index of HF components was not significantly increased, the difference was no statistically significant, p>0.05,frequency domain index in LF/HF components to reduce [1.54(1.65)vs 1.17(1.23),p<0.05], the difference was statistically significant. The VLF composition in frequency domain index did not see obvious changes, there was no statistically significant difference, p > 0.05. The composition of TP in frequency domain index did not show obvious changes, there was no statistically significant difference, p >0.05.Heart rate before and after the intervention group has significantly reduced,obvious statistical significance was found between [(73.21±10.80)times/min vs(63.93±6.18)times/min)],it has obvious statistical significance difference, p < 0.05.In the time domain index SDNN, RMSSD was no obvious change, there was no statistically significant difference,p>0.05. In control group, HRV in the frequency domain, time domain and heart rate were not obviously changed, there was no statistically significant difference, p>0.05. In the intervention group, SAI dimension score was lower than before, the difference was statistically significant[(60.60±5.90)vs(44.79±5.30),p<0.05], differences in the control group were also statistically significant [(59.88±5.83)vs(50.22±3.29),p<0.05],but the intervention group decreased more[(-14.40±4.66)vs(-10.00±3.91),P<0.05]. TAI dimension score of scale in the intervention group have statistical significance[(56.13 ±4.35)vs(52.91±4.36),P<0.05].While there's no statistical significance in the control group, P>0.05.HAMA score in the intervention group was statistically significant, [(25.51 ±2.66)vs(10.33±1.82),p<0.05],and so in the control group[(25.53±2.41)vs(15.11±2.77),p<0.05],and the intervention group decreased more[(-14.86±2.88)vs(-10.30±3.66),p<0.05]. The third study ? HR of all patients and SDNN in the baseline of HRV showed a negative correlation (r = -0.464, P <=0.000), RMSSD in the baseline of HRV and HR showed a negative correlation(r=-0.612, P <=0.000).Conclusions: The first study ?patients with generalized anxiety disorder have the character of neurotic traits, the emotion of these patients are less stability than normal people. The second study ?In the intervention group, HRV in the frequency domain index and heart rate changes, LF reflects the activity of the sympathetic nerve,LF component in frequency domain index decreased, which shows that the heart rate variability biofeedback training can reduce the excitability of sympathetic nerve. HF reflects the activity of the vagus nerve, it was no statistically significance. Frequency domain index the LF/HF components was reduced, the LF/HF reflects the balance of the sympathetic nerve and vagus nerve, which indicated heart rate variability biofeedback can improve the balance between sympathetic nervous system and the vagus nerve system, it is likely to promote the balance between sympathetic nerve and vagus nerve system. Heart rate in the intervention group was significantly decreased,heart rate variability biofeedback training can reduce the patient's heart rate, improve patient anxiety symptom. SAI score, TAI score and HAMA score in the intervention group and control group were both decreased before and after biofeedback, while scores of the intervention group were lower than the control group, it indicated that heart rate variability biofeedback training can help patients to relieve the patient's anxiety symptoms on the basis of the drug therapy. The third study. In clinical practice,it is likely to be early screening of susceptible individuals in the near future, which may lay the foundation for the prognosis and early intervention of patients. |
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