Preliminary Study Of The Acoustic Radiation Force Impulse Imaging Technology In The Application Of Hypothyroidism Disease In Pregnancy Women During The First And Second Trimester

Objective : To explore the clinical application value of Virtual touch tissue quantification(VTQ) and Virtual touch tissue imaging quantification(VTIQ)ofAcoustic radiation force impulse(ARFI) in hypothyroidism disease in pregnancy women during the first and second trimester.Methods:This study was conducted from July 2016 to January 2017 at the Second Affiliated Hospital of Kun Ming Medical University. A total of 65 subjects were registered as common hypothyroidism group, then according to 2011 ATA guidelines devided into two groups: Overt hypothyroidism(OH)group including 15 cases,Subclinical hypothyroidism(SCH) group including 50 cases.Then choose 35 cases euthyroidism pregnant women as the control group.In this study,we were using Siemens Acuson S3000 Helx diagnostic apparatus with acoustic radiation force impulse imaging technology and a 9L4 linear array probe(4.0-9.0MHz) .Bilateral thyroid size, shape,echo texture,superior thyroid artery peak systolic velocity (PSV )andresistance index(RI) were determined. Then using the VTQ and VTIQ technology measure the right lobe Shear wave velocity ( SWV ) .The software SPSS 21.0 is employed to analyze the all data.Results:1.No statistically differences were observed between the OH group, SCH group and control group about the volume, PSV and RI.2.Euthyroidism pregnancy women in the first and second trimester, using VTQ technology measured the shear wave velocity of the right thyroid lobe was 1.88±0.36m/s,using VTIQ technology measured the shear wave velocity of the right thyroid lobe was 2.12±0.17 m/s.3.Using VTQ technology, OH group VS control group, SCH group VS control group and OH group VS SCH group right thyroid lobe shear wave velocity show no statistically differences. But, there was statistically significant differences between common hypothyroidism group and control group ( P=0.042 ) .Using VTIQ technology,a clear difference was noted between OH group and control group(P=0.004);There was statisticallydifferences between SCH group and control group(P=0.045);But there was no statistically differences between OH group and SCH group.4.Compare VTQ to VTIQ technology, the shear wave velocity was statistically significant differences of SCH group and control group; But the shear wave velocity was no difference of the OH group. Compare VTIQ-C to VTIQ-B technology, the shear wave velocity was no difference of the OH group, SCH group and control group(P=0.313,0.161,0.191).5.Using VTQ and VTIQ technology, the shear wave velocity was no difference of SCH group during the first trimester and the second trimester. Using VTQ and VTIQ technology, the shear wave velocity of OH group and SCH group was not correlated with TSH.Conclusions:1. Conventional ultrasonography was limited in diagnosis of hypothyroidism disease during pregnancy.2. Euthyroidism pregnancy women in the first and second trimester, using VTQ technology measured thyroid right thyroid lobe shear wave velocity of was 1.88±0.36m/s; using VTIQ technology measured thyroid right thyroid lobe shear wave velocity of was 2.1210.17 m/s.3. VTQ and VTIQ technology can evaluate thyroid stiffness qualitatively and quantificationally.4. As the same patient , there was hugestatistically significant differences compare VTQ to VTIQ technology , so they are different technology.5. There was no differences between VTIQ-C and VTIQ-B technology,Both of them have advantages and disadvantages, can complement each other.6. The shear wave velocity was no differences between SCH pregnancy women between the first and the second trimester.7. The shear wave velocity was not correlated with TSH in each group.