| Objective:After the new standard iodized salt is fully covered,this study was to investigate iodine content of environment,iodized salt consumption of residents,urinary iodine levels of different populations,the iodine nutrition sources of vulnerable people,focued on understanding the population of thyroid function and prevalent of thyroid disease,Yunnan Province,Dali City.To explore the feasibility of Thyroglobulin(Tg)as an iodine nutritional biomarker of pregnant women,whether it could meet the needs of the mother when median urinary iodine of pregnant women at 100 ~ 150?g / L.To assess the current iodine nutrition levels of different populations and the scientificity and effectively of iodine deficiency disorders prevention in Yunnan province,to provide a scientific basis for monitoring and prevention of iodine deficiency disorders.Methods:1.To investigate the iodine content of drinking water in each administrative village of Dali City;to investigate the iodine consumption of households salt in 2012-2015;calculate the coverage of iodine salt,qualified rate of iodized salt,qualified iodized salt consumption rate.2.In the Dali City,select pregnant women,lactating women,school-age children,ordinary adult population,0~4 year-old infants and children,the subjects were questionnaires,detection of urinary iodine concent,thyroid ultrasonography,thyroid function,thyroglobulin,Cross-sectional survey of content.Calculate the urine iodine content of different populations and the prevalence of thyroid disease.Analyse of the feasibility of thyroglobulin and thyroid stimulating hormone as biomarkers of iodine nutrition in pregnant women.Results:1.The median iodine content of drinking water in Dali was 0.62?g / L,the range of iodine content was 0-9.92?g / L,and the iodine content of all drinking water was less than 10?g / L.2.The qualified iodized salt consumption rate of residents households salt was more than 90% per year from 2012 to 2015,median salt iodine from 29.38 mg / kg(2012)down to 24.96 mg / kg(2015)in Dali.city.3.The median urinary iodine in different populations were 136.85?g / L for pregnant women,102.63?g / L for lactating,164.03?g / L for adults,209.61?g / L for 8-10 years old children,157.27?g for children aged 0-2 years / L,134.08?g / L for 2-4 years old children.4.The average intake frequency of iodine-rich seaweed was 1 time / month,only 1.99% of the population through the multivitamin and minerals tablet to supplement iodine for pregnant women,lactating women.5.The median TSH of pregnant women,lactating women and childbearing age women were1.995,2.345,2.565 m IU / L,respectively.The median TSH were 1.850,2.030,2.235 mIU / L in the early,middle and late pregnancy stages,respectively.6.The prevalence of thyroid nodules was 14.70% and the Goiter rate was 1.6% in the adult population of Dali City.The prevalence of clinical hyperthyroidism and subclinical hyperthyroidism were 0.16%,0.47%,the prevalence of clinical hypothyroidism and subclinical hypothyroidism were 0.47%,7.09%,respectively,Both of TPOAb,TgAb positive rate was 9.22% in adult population.7.The median Tg of pregnant women,lactating women and childbearing age women were 10.49,9.28,9.66 ng / m L,which were less than 13 ng / mL.The ratio of more than 40 ng / m L was 1.90%,1.79% and 2.08%,respectively.8.The median Tg of early,middle and late pregnancy stages was 10.56,10.78,10.08 ng / mL,respectively,which less than 13 ng / m L,the proportion of more than 40 ng / mL in the early,middle and late pregnancy stages were 0,2.38%,3.28%,respectively.Only late pregnancy stages> 3%.Conclusions:1.The environment of Dali generally iodine deficiency,the population of iodine intake was mainly dependent on iodized salt.2.Dali City had completed salt iodine content reduction on time.3.After the reduction of salt iodine content,in Dali city,lactating women,ordinary adult population,<2-year-old children were in iodine nutrition adequate level,students were in more than adequate level.4.As an biomarker of iodine nutrition in pregnant women,Tg was better than TSH.5.Using Tg to evaluate,combined with the qualified iodized salt consumption rate was more than 90%,the median urinary iodine was between 100-150 ?g/L of pregnant women in Dali City,the overall iodine deficiency risk of pregnant women was low.However,in recent years,Dali City,non-iodized salt appeared in the market and salt system reform,needed to pay attention to individual iodine nutritional status of pregnant women and lactating women.6.After the reduction of iodine content,Dali was in a state of sustained elimination of iodine deficiency disorders,the overall level of thyroid disease at a low level. |
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