Clinical Sudy On Application Of Shangke Xiaozhong Tang(?????)for Treatment Of Postoperative Limb Swelling In Patients With Peroneotibial Fractures

Objective To observe the clinical curative effect of application of Shangke Xiaozhong Tang(?????,SKXZT)for treatment of postoperative limb swelling in patients with peroneotibial fractures.Methods One hundred and thirty-two patients with limb swelling after surgery for treatment of peroneotibial fractures included in the study which from The People's Hospital of Linyi City in Shandong Province in July 2015 to December 2016.They were randomly divided into 3 groups,44 cases in each group,and were treated with oral application of SKXZT combined with intravenous drip infusion of mannitol(group A)and monotherapy of oral application of SKXZT(group B)and monotherapy of intravenous drip infusion of mannitol(group C)respectively.The perimeters of legs of affected and unaffected side were measured and the swelling values of legs of affected side(perimeter difference of legs between affected and unaffected side)were compared between the 3 groups on postoperative day 1,3,5 and 7 respectively.Furthermore,the curative effects were evaluated on postoperative day 7 according to therapeutic effect evaluation standard of soft tissue injury which was extracted from guiding principles for clinical research on new Chinese medicine.Results There was statistical difference in the leg swelling values between time points,in other words,there was time effect.The leg swelling values decreased gradually during treatment(F=3154.562,P=0.000).There was statistical difference in the postoperative leg swelling values between the 3 groups in general,in other words,there was group effect(F=5.057,P=0.008).In multiple comparison.There was statistical difference in the postoperative leg swelling values between the group A and group B(P=0.007<0.0125),as well as between group A and group C(P=0.006<0.0125).There was no statistical difference in the postoperative leg swelling values between the group B and group C(P=0.974).There was interaction between time factor and group factor(F=33.757,P=0.000).On postoperative day 7,the group A surpassed the group B and group C in the clinical curative effects(Z=-3.772,P=0.000;Z=-5.136,P=0.000).There was no statistical difference between group B and group C in the clinical curative effects(Z=-1.533,P=0.125).Conclusion Application of SKXZT for Treatment of Postoperative Limb Swelling in Patients with Peroneotibial Fractures has an exact effect.Oral application of SKXZT combined with intravenous drip infusion of mannitol can reduce postoperative limb swelling in patients with peroneotibial fractures more quickly.So it is worthy of popularizing in clinic.