The Comparative Study Of The Sodium Hyaluronate Joint PRP Treatment Of The Early KOA In Rabbit

Objective To observe the influence of the expression of inflammatory factor IL-1?,TNF-exerted by the intervention treatment of sodium hyaluronate joint ?PRP and sodium hyaluronate joint dexamethasone,and to observe the morphologic variations of knee joint cartilage in the early KOA model of rabbits.Methods The 28 healthy adult rabbits were randomly divided into 5 groups: experimental group(sodium hyaluronate + PRP),control group I(sodium hyaluronate + dexamethasone),control group II(model set),blank control group and model checking group.There were 7 rabbits in the blank control group and 3 rabbits in the model checking group respectively,and there were 6 rabbits in the other each group.Except the 7 rabbits in the blank control group,the 21 rabbits in the remaining 4 groups were modeled by modified version of Hulth.After building model successfully,we injected sodium hyaluronate + PRP(0.2 ml + 0.5 ml)to all rabbits' right knees joint cavity in the experimental groups,and injected sodium hyaluronate with dexamethasone(0.2 ml + 0.5 ml)to the rabbits' right knees joint cavity in the control group I,and injected 0.9% normal saline 0.7ml to the rabbits' right knees joint cavity in the control group II.After intervention treatment of 5 weeks,once a week,we tested the level of TNF-and ?IL-1? in experimental group,control group I,control group II and blank control group rabbits,and observed the morphologic changes of articular cartilage under the microscope.Results: The value of IL-1? and TNF-? showed that experimental group,control group I and blank control group were all statistically significant(P < 0.05),compared with the control group ? respectively;the experimental group and the control group I had no statistical sinifictance(P > 0.05),,compared with the blank control group respectively;the experimental group had no statistical significance(P > 0.05),compared with the control group I.The morphology of articular cartilage showed that the protection and repair of cartilage in experimental group were better than that in control group I.Conclusion:Sodium hyaluronate +PRP has high potential value in the treatment of early KOA.