To Explore The Curative Effect Of Incision Decompression To Crush Syndrome Of Rabbit Model

Objective: Aim to observe the treatment effect of Fascia incision decompression in the crush syndrome of rabbit model,which could guide the clinical treatment.Methods: A total of 70 healthy adult New Zealand rabbits（both male and female）were selected,randomly divided into control group without Incision decompression（10）and Incision group（60）.In crush injury group the Squeezed limb was decompression after extrusion 4 hours,then according the times of Fascia incision decompression,we divided into six subgroups（10 in each group）:0 hour,after 2 hours,after 4 hours,after 6 hours,after 8 hours,after 10 hours,labeled A-F group,Respectively,control group is set to group G.Measuring BUN,Cr,AST,ALT,CK,CK-MB,K⁺,Ca²⁺ and MYO in group A-G after decompression 4 hours and Incision group（group A-F）after Incision decompression 2 hours,6 hours and 12 hours.After 24 hours the location of the extrusion quadriceps,kidneys,liver,myocardium were taken for pathological analysis.Results: The BUN,Cr,AST,ALT,CK,CK-MB,K⁺,Ca²⁺,MYO after decompression 4 hours and at various time points after Incision decompression had no statistical significance in Incision group（including subgroups）and control group（P>0.05）;Crush injury group and the control group at various time points and biochemical index difference had no statistical difference（P>0.05）;The biochemical index such as BUN,Cr,AST,ALT,CK,and CK-MB was rising over the time in each subgroups and K ⁺,Ca²⁺,MYO was decline,On the contrary（P<0.05）.Conclusion: There is no obvious curative effect in the rabbit model with crush syndrome for incision decompression treatment in early time.