Effects Of Different Peritoneal Transport Characteristics On Vascular Endothelial Function And CRP And Hcy In Peritoneal Dialysis Patients

Objective:In this paper,brachial artery FMD as an indicator of vascular endothelial function,high sensitivity C-reactive protein(CRP)to measure micro-inflammation indicators,to observe the effects of different peritoneal transport characteristics on vascular endothelial function and CRP and Hcy,and to provide clinical basis for assessing cardiovascular events.Methods:A total of 70 patients with continuous ambulatory peritoneal dialysis(CAPD)were enrolled in the Nephrology Department,the First Hospital of Shanxi Medical University from January 2015 to December 2016.According to the peritoneal balance(PET)test,it was divided into two group,high transit group and low transit group,record the patient’s general condition,detection of patients with plasma hypersensitive CRP,homocysteine(Hcy),serum creatinine(Scr),blood urea(BUN),serum albumin(ALB),serum calcium(Ca),serum phosphorus(P),parathyroid hormone(iPTH)and other biochemical indicators.Blood vessel dilatation(FMD)mediated by brachial artery blood flow was used to assess vascular endothelial function,to investigate the effects of different peritoneal transport characteristics on vascular endothelial function and CRP and Hcy.The SPSS 19.0 software package was used for statistical analysis.Results:1.There were no significant differences in sex,age,body mass index(BMI),dialysis age and primary disease between the two groups(P>0.05);Ca、P、iPTH、BUN and Scr was not statistically significant;Compared with the low transit group,the ALB of the high transit group was significantly decreased,The difference was statistically significant(P<0.01).2.There was no significant difference between the two groups in primary disease(P>0.05).3.The FMD(3.96 ± 1.11)% of the high transporter group was lower than that of the low transporter group(6.05 ± 0.95)%(P<0.01).;The median level of CRP in high transit group(3.88)mg / L was higher than that in low transit group(2.82)mg / L(P <0.05);The high transport group Hcy(29.88 ± 2.25)mol / L was lower than the low transit group(31.90 ± 2.21)mol / L,The difference was statistically significant(P <0.01).4.The FMD of patients with PD was negatively correlated with CRP levels(r=-0.235,P<0.01);There was no correlation between FMD and Hcy(P>0.05).Conclusion:1.Peritoneal dialysis patients have varying degrees of vascular endothelial dysfunction,The high transporter group had a higher degree of disorder,and vascular endothelial dysfunction and CRP levels are closely related,Suggesting that improving microinflammatory state can improve vascular endothelial dysfunction.2.Peritoneal dialysis patients always have high homocysteinemia,The level of Hcy in patients with high peritoneal transport was lower than that in low transporter,May be associated with peritoneal dialysis on homocysteine clearance.3.Control of peritoneal dialysis patients,especially peritoneal hypervascular status of vascular endothelial dysfunction and microinflammatory levels in the body to reduce cardiovascular events are important.