The Investigation Of Relevance Between Carotid Intima-media Thickness And Plaque And Coronary Heart Disease

Objective:To investigate the difference between carotid intima-media thickness and plaque in patients with coronary heart disease(including single-vessel disease,double-vessel disease and three-vessel disease)and non-coronary heart disease(CHD)and its correlation with the severity of coronary artery disease.To study the correlation between the nature of carotid plaque and coronary heart disease.Methods:Selected samples of total 104 patients who were admitted as coronary heart disease(CHD)during September 2016 to January 2017 at Shanxi Provincial Cardiovascular Hospital,Department of Cardiology due to chest tightness,chest pain who were required to conduct as coronary angiography to be diagnosed.According to the results of coronary angiography,it was divided into coronary heart disease group(including single disease group,double vessel disease group and three lesions group)a total of 82 cases and 22 cases of healthy control group.The patients were admitted to the hospital for routine clinical data,including age,sex,smoking history,history of drinking,family history,history of hypertension,history of diabetes mellitus,history of cerebrovascular disease,and blood lipid status after admission,All patients underwent carotid artery ultrasonography to measure the carotid intima-media thickness and plaque.Comparison of the four groups of patients among the basic information,carotid atherosclerosis and coronary lesions of the difference.Results:1.When comparing the proportion of male patients of three lesion group with the other groups,the differences have statistically significances.(P<0.05);the smoking rate of the triple vessel lesions patients was 58.50%,which is higher than the other three groups,the differences have statistically significances(P<0.05)the EF value of Healthy controls' s differences were statistically significance comparing with the other three groups,(P<0.05);2.Four groups of patients' CIMT values Respectively are 0.98±0.2mm,1.14±0.17 mm,1.24±0.10 mm and 0.86±0.14 mm.And the differences of CIMT values in the four groups have statistical significances.The plaque numbers(0.59±1.05)in the healthy control group was significantly lower than that in the single vessel disease group(2.16±1.26),double vessel disease group(2.23±1.07)and three vessel disease group(2.44±1.12).However,the difference of the coronary heart disease lesion counts group was no statistically significances.3.Four groups of patients have absolutely differences on the detection of flat spot,soft spot,hard spots,and the differences have statistical significances.(P.ave<0.05),but they have no significant differences on ulcer plaque.The plaque type detection rates from high to low are: hard spot > flat spot > soft spotd> ulcer spot;4.Relevance of CIMT and plaques and Gensini score are positively related(the respectively r value is 0.509?0.401?0.458,P.ave<0.001).Conclusion:1.CIMT can reflect the occurrence and severity of coronary artery disease,not only in the number of coronary artery vessels in the number of vascular lesions in the degree of stenosis,CIMT on the diagnosis of coronary heart disease have a certain reference value;2.The number of plaque pathology and atherosclerosis can reflect the degree of coronary artery disease,and the correlation is better than CIMT;3.Combined with the basic situation of patients and carotid ultrasound can improve the accuracy of diagnosis of coronary heart disease,but due to the limitations of color ultrasound itself,it need to find a more objective and accurate way to help the clinic.