Preparation And Characterization Of Potato Starch Nanoparticles And Their Sustained Release Properties As Drug Carrier Materials

With potato starch as raw material,Preparation of starch nanoparticles by ultrasonic assisted acid hydrolysis,and the particle size and the yield of the particle as the index,The effects of sulphuric acid concentration,acid hydrolysis time and ultrasonic power were studied,The optimum process parameters were obtained,and the physical and chemical properties of the starch nanoparticles prepared under the optimum conditions were investigated;With the preparation of starch nanoparticles as carrier material,5-aminosalicylic acid(5-AS A)as the main drug,used for wet granulation tableting has a core chip core is arranged in the simulated gastrointestinal reaction artificial environment,the cumulative response after a certain time of drugs in different medium by testing the core effect of drug release percentage drug release starch nanoparticle carrier material,The sustained-release tablets core after enteric coated tablets,will be placed in simulated gastrointestinal tract environment of drug release test,while the accumulation in different media release percentage in vitro drug release kinetics model;Us ing Escherichia coli as the indicator bacteria,the release of 5-ASA at different time points was verified by measuring the size of the bacteriostatic ring in Oxford cup:1 Use original starch by ultrasonic pretreatment,observed by FE-SEM cracks,pits and grooves surface after acid hydrolysis of starch,after analysis of the product size,yield the optimal preparation parameters were as follows: under the condition of 40 ℃,with 3 mol/L sulfuric acid hydrolysis of starch 15%,stirring speed 100 r/min,ultrasonic power 400 W,20 h after acid hydrolysis,the starch particle size in the range of nm 50~80,the yield was 14.1%.2.Compared with starch nanoparticles of starch and optimal process parameters for preparation,crystallinity increased from 21.57% to 46.35%,water absorption rate increased from 34.8% to 96.9%,the adsorption rate increased from 49.1% to 93.7%,the specific surface area increased from 0.1789 m2/g to 1.6491 m2/g,nitrogen adsorption capacity increased from 0.68374 cm3/g to 1.34734 cm3/g.3.5-ASA based medicine,respectively using starch and starch nanoparticles as carrier material,wet granulation lame1 lar core to simulate artific ial gastrointestinal fluid as release medium,dynamic dialysis method was used to release test and statistics of different release cumulative drugs after a certain reaction time in the medium of drug release rate.The results showed that: when the chip core was simulated for a certain period of time in the human body,the cumulative release percentage was lower than that of the original starch.4.The sustained-release tablets were coated with enteric coated tablets and the sustained-release tablets were placed in the simulated artificial gastrointestinal environment,and the cumulative drug release rate of the drugs in different release media was measured.The results showed that the sustained-release coated tablets in artificial gastric juice was 2 h without drug release,transformation medium for small intestine f luid p H6.8,after 3 h accumulative release rate reached 22.381%,continue to transform the medium for the colon fluid environment pH7.8 in 10 h drug release rate reached 87.059%,the drug of colon targeting give medicine.5.With Escherichia coli as indicator,the release rate of the sustained release coated tablets was tested by bacteriostatic test.The results showed that the sustained-release coated tablets in simulated gastrointestinal environment in the cumulative drug release rate continued to increase in the reaction after 15 h cumulative release rate reached 87.1%,the antibacterial circle is 25.67 mm,indicating that the drug release in the colon fluid,played in the colon drug efficacy.