A Retrospective Investigation Of The Association Between Ambient Air Pollution And Birth Weight In Baoding

Objectives:Objective to investigate the incidence of low birth weight?LBW?and air pollution in Baoding from October 28,2013 to October 28,2016 at the Affiliated HosPital of Hebei University,exposure to air pollutants and the relationship between air pollutants and birth weight in pregnant women.And then to explore the influencing factors of low birth weight in neonates.Ultimately provide theoretical support for the development of relevant interventions,so as to improve the quality of the population.Methods:1 Delivery registration charts,medical records and Prenatal health care system records from October 28,2013 to October 28,2016 at the Affiliated HosPital of Hebei University were reviewed and analyzed.The baseline data collected included age,degree of Education,prepregnancy BMI,delivery number,birth season,gestational weeks and risk factors of pregnant women in the database?gestational hypertension,gestational diabetes?,date of delivery,gestational age,birth time;birth weight.2 Air pollution status including AQI,PM_2.5,PM₁₀,SO₂,NO₂,CO and O₃ levels were provided by the environmental monitoring station of Baoding.3 Birth weight?Birth weight,BW?is first times the weight of the newborn within first hours after birth.According to the seventh edition of“Pediatrics”,According to birth weight,the newborn was divided into four categories,2500g?weight?4000g were considered normal weight,1500g?weight <2500g were considered low birth weight,weight <1500g for very low birth weight,weight >4000g macrosomia ? The present study,infants were divided into low birth weight group and non low the birth weight group,and calculate the incidence of low birth weight.Single factor analysis of variance according to each factor was performed to find out the influencing factors oflow birth weight.There were statistically significant differences in variance analysis as independent variables,neonatal birth weight as the dependent variable,multiple linear regression analysis were applied to the quantitative effects of air pollutants on birth weight.Statistics were Performed using SPSS22.0.Result:1 Incidence rate of low birth weightBirth weights of 1174 newborns were collected.Of these,89 had LBW.The incidence rate of LBW was 7.58%.The incidence rate of LBW was significantly higher among multiPle births than among single births?28.57%versus 7.33%;?2=8.910,P<0.05?.The incidence rate of having newborns with LBW was significantly higher among pregnant women with hypertension than those without hypertension?33.83%,4.23%;?2= 147.559,P<0.05?.2 Baseline data on birth weightSingle factor analysis of variance showed that there were no significant differences between the different age groups,education level,prepregnancy BMI group,delivery season group,prepregnancy diabetes and low birth weight.There were significantly differences in the incidence of low birth weight and number of births.Multiple linear regression analysis shows that the incidence rate of having newborns with LBW was 12.218 higher among pregnant women with hypertension than those without hypertension.3 Air pollution situationBaoding city environmental monitoring station data showed that air pollution in October 28,2013-October 28,2016,the daily average concentration of the seven air pollution index were as follows: AQI148.43+92.134g/m3;PM2.5107.57±86.655?g/m3;PM10182.72±122.330?g/m3;S O254.68±48.391?g/m3;NO2 55.55±30.198?g/m3;CO 1.8935±1.58936?g/m3;O358.31±36.212?g/m3.4 Effect of ambient air pollution on birth weightSingle factor analysis shows that AQI levels during the entire pregnancy and the second and third trimesters were each significantly associated withbirth weight?P<0.05?.PM2.5 exposure level during the pregnancy was significantly associated with birth weight?P<0.05?.SO₂ exposure levels during the entire pregnancy and the second and third trimesters were each significantly associated with birth weight?P<0.05?.CO exposure level during the pregnancy was significantly associated with birth weight?P<0.05?.PM₁₀ exposure levels during the entire pregnancy and the second trimester were significantly associated with birth weight?P<0.05?.Multiple linear regression shows that the incidence rate of having LBW was 2.127 times higher with each IQR increase of SO₂ exposure level.The incidence rate of having LBW was 0.348 times lower with each IQR decrease of SO₂ exposure level.Conclusion:1 Maternal hypertension in pregnancy is a risk factor for low birth weight infants2 Exposure to SO₂ during pregnancy increase the risk of low birth weight infants.3 Exposure to SO₂ at late pregnancy reduces the risk of low birth weight infants.