| Objective:The medication rule of objective evaluation of traditional Chinese medicine in the treatment of metabolic syndrome and to evaluate curative effect of removing phlegm and Blood Stasis Decoction in the treatment of metabolic syndrome, TCM treatment of metabolic syndrome and provide a reference of the use of evidence-based support.Methods:1 For the past 30 years in the treatment of metabolic syndrome of traditional Chinese medicine used to collect statistics, the use of SPSS13.0 statistical software, the frequency of common drugs and the frequency of statistical analysis2 From the first part, it can be concluded that phlegm and blood stasis play an important role in the development of metabolic syndrome,in accordance with the guiding principles of evidence-based medicine, collection of removing phlegm and Blood Stasis Decoction Combined with western medicine in the treatment of metabolic syndrome clinical randomized controlled study, selected studies that met the inclusion criteria. The bias risk assessment of included studies were evaluated using NoteFist4.1 software for document management, the use of Excel2013 information extraction and production a study on information registration form. "Using Review Manager 5.3 software, included in the study of statistical analysis, the statistical analysis of not descriptive analysis, and interpretation of forest map, Test for publication bias using funnel plots Cochrane method recommended by Handbook. Clinical evaluation of removing phlegm and Blood Stasis Decoction in the treatment of metabolic syndrome and safety.Results:1 A total of 87 literatures, 145 kinds of flavor to Chinese medicine, the total frequency of 804 times, the frequency of the use of drugs by followed by Salvia miltiorrhiza, Radix Astragali, Rhizoma alismatis, pinellia, Poria, hawthorn, dried tangerine peel, Coptis chinensis, Rhizoma Chuanxiong and so on. The categories of drugs use frequency from more to less followed by tonic medicine, promoting blood circulation medicine,antipyretic, dampness phlegm medicine, medicine and so on.2 A total of 2 randomized clinical trials of 18, the total number of cases in 1329 cases,the test time is 30-90 days. (removing phlegm and Blood Stasis Decoction Combined with western medicine treatment of metabolic syndrome in the total efficiency of Meta analysis, combined with the total efficiency of group MS was superior to the control group, the difference was statistically significant [RR1.27,95%CI (1.16,1.40). (removing phlegm and Blood Stasis Decoction Combined with western medicine treatment of metabolic syndrome weight Meta analysis, influence of BMI group is superior to the single use of antihypertensive + + hypoglycemic lipid-lowering group, hypoglycemic drug group, the difference was statistically significant [MD-0 .46,95%CI (-0.90, -0.02);MD-0.13,95%CI (-0.24, -0.01). With the improvement of WHR level group than the control group, there were statistically significant differences in [MD-0.07,95%CI (-0.09,-0.04). With the improvement of WC level group than the control group, there was significant difference between the [MD-1.27,95% CI (-2.38, -0.16) (Huayu Prescription drug. Combined with western medicine treatment of metabolic syndrome refers to the analysis, the changes of blood pressure index of SBP modified Meta Good, combination group is better than the single use of hypoglycemic lipid-lowering and antihypertensive ++ group hypoglycemic drug group, there were statistically significant differences in[MD-3.60,95%CI (-6.89, -0.32); MD-6.80,95%CI (-8.19, -5.41) on the improvement of DBP. And the combined group were better than the single use of hypoglycemic lipid-lowering and antihypertensive + + group hypoglycemic drug group, the differences were statistically significant [MD-4.48,95%CI (-5.59, -3.38); MD-2.08,95%CI(-4.64,0.48) group and Atorvastatin Calcium Tablets group jointly. Lovastatin Tablets,metformin + group and metformin tablets plus captopril group compared can reduce blood pressure of patients, the differences were statistically significant (P < 0.05).(removing phlegm and Blood Stasis Decoction Combined with western medicine treatment of metabolic syndrome group analysis, blood glucose index Meta combined group of FBG improvement is superior to the single use of antihypertensive lipid-lowering hypoglycemic + + group and there was a significant difference between the [MD-0.46,95%CI (-0.79, -0.13)]; but with the single use of hypoglycemic agents was not significant, no significant differences in [MD0.12,95%CI (-0.09,0.33)]; PG2h The improvement, the treatment group and the control group had no significant difference,there was a significant difference between the [MD-0.01,95%CI (-0.48,0.46). Effects of HbAlc, no difference between the treatment group and the control group, there was no significant difference between [MD-0.04,95%CI (-0.14,0.06). (removing phlegm and Blood Stasis Decoction Combined with Western Medicine treatment on metabolic syndrome and changes of blood lipid indexes, Meta analysis effect of the TC joint group than the control group, there were statistically significant differences in [MD-0.79, -1.52,-0.06]. on the TG effect, combined with Group is better than the single use of antihypertensive lipid-lowering hypoglycemic + + group, there were statistically significant differences in [MD-0.37,95%CI (-0.68, -0.06). But with hypoglycemic group have no difference, no statistically significant differences in treatment group[D-0.19,95%CI two (-0.57,0.20)], and the results are robust. The influence of HDL-c,combined group was superior to the single oral antihypertensive + + hypoglycemic and lipid-lowering group group, there were statistically significant differences in[MD0.27,95%CI (0.07,0.48); MD0.11,95%CI (0.03,0.20). The improvement of LDL-c,treatment group is better than the single use of hypoglycemic lipid-lowering +antihypertensive + control group, there was no significant difference in [MD 0.11,95%CI(-0.27,0.49). But with hypoglycemic group have no difference, no significant differences in [MD-0.20,95%CI (-0.45,0.04). (stasis expectorant drug in treatment of metabolic syndrome and insulin sensitivity index Meta analysis on FINS to improve the level and combined group than the control group, there were statistically significant differences in[MD-1.62,95%CI (-2.08, -1.16)] The influence of the INS2h. The combined group was better than that of metformin group, the difference was statistically significant (P < 0.05).The influence of the IRI; combination group is better than the single use of antihypertensive lipid-lowering hypoglycemic + + group, there were statistically significant differences in [MD-0.45,95%CI (-0.61, -0.29). But no difference and hypoglycemic drug group, no significant difference the significance of [MD -0.10,95%CI(-0.59,0.39). Effects of ISI, combined group is better than the single use of antidiabetic antihypertensive lipid-lowering + + group, the difference was statistically significant (P <0.05), blood stasis. Prescription medicine combined with western medicine group on the MS CRP level of improvement than the control group, the difference was statistically significant (P < 0.05). The adverse reactions and removing phlegm and Blood Stasis Decoction Combined with western medicine group than the control group.Conclusion:According to the analysis of drug law, drug category of traditional Chinese medicine in the treatment of metabolic syndrome with tonic, blood stasis, wet expectorant drugs,the most commonly used herbs are salvia, astragalus, Alisma, hawthorn, pinellia, Poria,and dialectical theory of governance, with card to add and subtract.Through the systematic evaluation of the included studies, removing phlegm and blood stasis prescription in the treatment of MS efficiency is superior to the control group,can improve the MS of patients with BMI, WHR and WC, reduce the level of blood pressure in patients with MS, improve the secretion of INS2h and FINS, ISI, TC and TG decreased in patients with MS level, increased HDL-c level; blood stasis prescription drug group decreased PG2h, HbAlc levels compared with the control group no difference; in improving HOMA-IR, FBG, LDL-c level, curative effect is exact, but because of the low quality of the included literature, randomized clinical trials are the Where there are imperfections, more high-quality research is needed to confirm the above conclusions... |
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