Characteristics Of Syndrome Elements Of Syndrome Drift During Antiviral Treatment In Chronic Hepatitis B(CHB)with Damp-heat Stagnation Syndrome

ObjectiveTo observe characteristics of syndrome elements of syndrome drift during antiviral treatment in chronic hepatitis B(CHB)with damp-heat stagnation syndrome and enrich the perseverance of Chinese medicine.Understanding the law of the change of the syndrome meticulously,so we can grasp the changes of the syndrome more accurate and improve the curative effect.MethodsSyndrome drift was defined as emerging signs or symptoms inadequate for being recognized as another pattern of syndrome else.The subjects of this study were the CHB patients with damp-heat stagnation syndrome who were receiving antiviral therapy during the period from February 2016 to May 2017 in Xiamen Hospital of TCM.A total of 168 CHB patients were recruited in this study.We recorded their four diagnostic information every 2 weeks till 3 months.The follow-up was ended if the syndrome drift occurred in the 3-month period.Hence,we analysed all the four four diagnostic information through a software developed by Fujian University of TCM Research Base,and then induced the syndrome elements.Results1.The study enrolled 168 patients in total,104 cases(61.9%)of which emerged syndrome drift.During observation,6 cases(3.6%)were shed.2.This study found that age,gender,HBeAg,ALT,TBil,HBV DNA,G,along with S weren't the independent factors of syndrome drift.3.In end of the observation,new-onset syndrome were fatigue(37cases,35.6%(95%CI:26.6%,45.6%)),bleeding gums(22 cases,21.2%(95%CI:14.0%,30.5%)),insomnia(19 cases,18.3%(95%CI:11.6%,27.3%)),dreaminess(13 cases,12.5%(95%CI:7.1%,20.8%)),abdominal distention(13 cases,12.5%(95%CI:7.1%,20.8%)),easy to wake up(13 cases,12.5%(95%CI:7.1%,20.8%)).(each coverd more than 10%of total cases)4.In end of the observation,the new-onset disease location were bladder and thoracic diaphragm.The difference of bladder was not statistical significance(?2=1.005,P= 0.316).The difference of thoracic diaphragm was not statistical significance(?2=3.044,P = 0.081).5.In end of the observation,the new-onset disease nature were cold,wind-stirring,helminthic accumulation,yin deficiency,qi sinking.The difference of cold was not statistical significance(?2=3.044,P = 0.081).The difference of wind-stirring was not statistical significance(?2=1.005,P = 0.316).The difference of helminthic accumulation was not statistical significance(?2=1.005,P = 0.316).The difference of qi sinking was not statistical significance(?2=2.019,P=0.155)?yin deficiency had statistical significance(P = 0.000).ConclusionIn the observation,about half of cases emerged syndrome drift.This study found that age,gender,HBeAg,ALT,TBil,HBV DNA,G,along with S weren't the independent factors of syndrome drift.The new-set syndrome element was yin deficiency.