Study On Standardizied Diagnosis And Treatment System Of The Syndrome Of Damp-heat In The Liver And Gallbladder Of Chronic Hepatitis B

Objective: Through investigating the characteristic of the dampness-heat syndromeof liver and gallbladder,to explore the relationship between objective indicators andchronic hepatitis B,in order to establish clinical standardized therapeutical system of thesyndrome of Damp-heat in the liver and Gallbladder of chronic Hepatitis B.Methods:160patients diagnosed as Damp-heat in the liver and Gallbladder wererandomly assigned to two groups: the treated group(100cases) treated with Jiayi clearingdecoction and the control group (60cases)treated with prescription specialise for hepaticinjury. One side, clinical symptoms of the treated group were analyzed by, to establishstandardized differentiation of the syndrome of Damp-heat in the liver and Gallbladder. Atthe same time, to anlyze the relationship between symptome point and liver function,HBV-DNA and ultrasonic check. On the other side, clinical symptoms,physical sign,liverfunction,ultrasonic check,PT,four indexes of liver fibrosis and CD4+,CD8+,CD4+/CD8+were observed and compared before and after therapy in the treated groupand between the two groups after therapy.Results:1.Standard of the syndrome differentiation: main symptoms: distending painin hypochondrium,irritable and angry easily;secondary symptoms: deep-colored urine,yellow fur,yellow eyes,yellow tongue coating;thirdly symptoms: greasy and bitter taste,halitosis,viscous stool,thirst without desire to drink,anorexia,nausea,tiring greasy food,insomnia,dreaminess,weakness,abdominal distension and pain,red tongue,wiry androlling and rapid pulse; objective indicators: light or middle increase of ALT,AST,TBIL, DBIL,GLO; light or middle change in ultrasound parameters.2. Proportional analysis: thesyndrome of Damp-heat in the liver and Gallbladder is apparently positively proportionalto ALT,AST,GLO,TBIL,DBIL,IBIL,ultrasound parameters,degree of illness(P<0.01),and negatively proportional toALB,A/G(P<0.01).3. Therapeutical program:Jiayi clearing decoction obviously improved liver function,liver and spleen's ultrasoundparameters,four indexes for liver fibrosis,PT and CD4+,CD8+,CD4+/CD8+(P<0.05,P<0.01). Jiayi clearing decoction is cardinal prescription for the syndrome of Damp-heatin the liver and Gallbladder of chronic Hepatitis B.4.Establish curative effection judgmentsystem.Conclusions: The syndrome of Damp-heat in the liver and Gallbladder of chronicHepatitis B have some correlation with liver function, on the basis of it, we can establishdouble therapeutical program of the syndrome of Damp-heat in the liver and Gallbladderof chronic Hepatitis B.