The Role Of Galactose-deficient IgA1 In Children With Henoch Schonlein Purpura Nephritis

Objective:To explore the role of galactose-deficient IgA1 in children with Henoch-Schonlein purpura nephritis.Methods:Sixty-seven children that were confirmed as henoch-Schonlein purpura nephritis were enrolled(HSPN group),and 57 case of henoch-Schonlein purpura(HSP group)as well as 15 case of isolated hematuria were also selected.twenty healthy children served as the healthy control group.The levels of serum and urinary galactose-deficient IgA1 in each group were detected with ELISA.Results:(1)The level of serum Gd-IgA1 in HSP group and HSPN group were significantly higher than that in isolated hematuria group and healthy control group(P<0.01).However,the level of serum Gd-IgA1 levels in HSPN group was more higher than HSP group(P <0.01).(2)Similarly,the level of urinary Gd-IgA1 in children with HSP group and HSPN were significantly higher than that of isolated hematuria group and healthy controls group(P<0.01).the level of urinary Gd-IgA1 levels in HSPN group was more higher than HSP group(P <0.01).(3)Serum and urinary Gd-IgA1 levels in children with HSPN group were positive correlated with 24-hour urinary protein quantitative and Renal Pathologic Grading(P<0.05).(4)the levels of Gd-IgA1 in blood and urine of HSPN group were not associated with hematuria(P>0.05).(5)When the levels of serum Gd-IgA1 ?1485.58U/mL and(or)urinary Gd-IgA1/ urinary creatinine ratio ?105.74U/mg,Children with HSP are more likely to be associated with renal injury.Conclusion:Serum and urinary excretion Gd-IgA1 may be a biomarkers of pediatric HSPN,which is of some significance for the initial assessment of whether or not HSPN is associated with renal damage.The levels of Gd-IgA1 in serum and urine of children with HSPN were positive correlated with 24-hours urine protein and Renal Pathological Grade.