A Case Report Of Primary Sj(?)gren's Syndrome With Bradykinesia?Rigidity As The First Manifestation

Background and purposePrimary Sjogren's syndrome is a chronic systemic autoimmune disease characterized by xerophthalmia and xerostomia,it can experience extra glandular features including autoimmune pancreatitis,renal tubular acidosis,interstitial lung disease,lymphocyte proliferation and nervous system.A variety clinical manife-station of neurologic disorder,including peripheral nervous system and central nervous system,central nervous system involvement is rare,and often central nervous system as the first manifestation,therefore,in the process of diagnosis is misdiagnosed easily.Previous studies primary Sjogren's syndrome with multiple sclerosis ? neuromyelitis optica ? central nervous system vasculitis as the first manifestation.But primary Sjogren's syndrome with bradykinesia?rigidity as the first manifestation is rare,and is not easy to diagnosis.In this paper,a case of primary Sjogren's syndrome with bradykinesia?rigidity as the first manifestation and review of related literature,in order to improve the clinical diagnosis of primary Sjogren's syndrome with bradykinesia?rigidity as the first manifestation accuracy.MethodA retrospective analysis of a confirmed primary Sjogren's syndrome with bradykinesia?rigidity as the first manifestation and the diagnosis of the disease,possible pathophysiology,clinical features,imaging features,treatment and prognosis of a discussion.According to the China Parkinson's disease diagnostic criteria(2016):bradykinesia and rigidity or tremor is Parkinsonism.In order to"????????????????Parkinsonism?Primary Sj?gren's syndrome"and other search terms manually from 1993 to March 2018 in between CNKI,VIP,Wanfang and Pubmed and other databases on the primary Sjogren's syndrome with bradyki-nesia?rigidity as the first manifestation with complete case data and analysis.Results1.For the first time,a case of primary Sjogren's syndrome with bradykinesia?rigidity as the first manifestation,treatment is difference form primary Parkinson'sdisease,suggesting that glucocorticoid is the most effective treatment for the disease;2.Retrieved from 1993 to March 2018 in the database on the primary Sjogren's syndrome with bradykinesia?rigidity as the first manifestation of the literature,found that there are few reports with complete cases.Combined with this case involving primary Sjogren's syndrome with bradykinesia?rigidity as the first manifestation,a total of 5 cases of data.Primary Sjogren's syndrome with bradykinesia?rigidity as the first manifestation is rare,It is thought that Primary Sjogren's syndrome may be caused by the inflammatory mechanism involved in the substantia nigra-striatal system system,resulting in Parkinsonism,However,it is still needed to be further confirmed by gene?PET CT.ConclusionBradykinesia?rigidity as the first manifestation with dry mouth and dry eyes of Parkinsonism,should be alert to primary Sjogren's syndrome.