Research On The Clinical Application Of Gancao Xiexin Tang Based On Acrid Openning And Bitter Descending And Sweet Coordinating

1 Objective:The theory of Acrid Openning and Bitter Descending and Sweet Coordinating is from Huangd’s Internal Classic.Zhang Zhongjing inherit and developed the theory,constitute many famous prescription.Gancao Xiexin Tang is one of the famous Xiexin decoction recipes,fully embodied the theory of Acrid Openning and Bitter Descending and Sweet Coordinating.Zhang Zhongjing writed down detailedly its etiology and pathogenesis,symptom,prescription,decoction method in Treatise on Cold Damage Diseases and Synopsis of the Golden Chamber.Later physician and modern Traditional Chinese Medicine clinical experts continue thorough research.The pathogenesis of Gancao Xiexin Tang is deficiency of the spleen and stomach,intertwist of cold with heat,hot and humid intrinsic.It is correspond many modern diseases.The prescription has a strong practical significance.The thesis research the clinical application of Gancao Xiexin Tang based on Acrid Openning and Bitter Descending and Sweet Coordinating can provide some reference for clinical work.2 Methods:2.1 Chapter 1 Theoretical part Combined with the ancient physicians and modern physicians of the discussion,summed up Xin Kai bitter Gan Gan method and licorice Xiexin Tang prescription law.2.2 Chapter II Medical Case Study Making fully use of CNKI,WF,Web of Know and library to search literature on Gancao Xiexin Tang.The president collected 128 valid medical records.Gender,age,symptoms,tongue,pulse,addition and subtraction dose changes,symptoms,TCM disease name,disease name Western medicine is normalized in each case.Building database,conducting frequency statistics and analysis in order to explore its laws.3 Results:3.1 The result of theoretical research The firs,Acrid Openning and Bitter Descending and Sweet Coordinating is from the "Nei Jing",prescription compatibility application is mainly embodied in Zhang Zhongjing’s Xiexin decoction recipes,later disease physicians play a wider range of disease.The second,composition principle: cold temperature sharing,to reconcile the yin and yang;strengthening healthy qi to eliminate pathogens;acrid to diffuse and bitter to descend,egulating activities of qi;sweet to co ordinate,in order to prevent too hasty.Features:egulating activities of qi,to reconcile the spleen and stomach;reconcile yin and yang,attack and complement both;compatible with a combination of flexible.The third,clinical application:Zhang Zhongjing used to syndromes of discord of cold and heat and disorder of activities of qi of Spleen and stomach and liver and gallbladder.Later physicians to Ye Tianshi as the representative is also reflected in the Xiexin Tang side of the addition and subtraction cut.The fourth,source of Gancao Xiexin Tang:Zhang Zhongjing used in the spleen card and fox-puzzle syndrome;later physicians used in fasting dysentery,celiac disease,horse horse rickets,chronic infantile convulsion and so on.The fifth,etiology and pathogenesis: weakness of spleen and stomach,table evil retraction;cold and heat mixed,abnormal movements;damp heat intrinsic,confliction between vital-qi and pathogens.The sixth: to add dangshen is more reasonable,licorice for the king medicine,most medicine attributed to the spleen,stomach,to dig and then fried necessary.The seventh,modern physicians are used in mucosal-associated diseases,immune disorders,and psychiatric disorders.3.2 The results of modern medical research The first,There was no significant difference in sex,the age of onset between 20-60 years old.The second,clinical indications,the main symptoms: oral ulcers,abdominal distension pain,poor appetite,loose stools,upset,drowsiness fatigue,dry mouth,skin itching,insomnia sleep poor,throat discomfort,perineal discomfort,diarrhea,joint pain;Pale or red tongue,thin white or thin yellow fur;pulse like Shen,vein-based.The third,Drug law,the main drug composition is licorice,Pinellia,ginger,scutellaria,berberine,codonopsis,jujube;dosag:Licorice 17.50 ± 9.87,Pinellia15.02 ± 10.06,ginger 9.55 ± 5.28,Scutellaria 11.19 ± 5.88,Coptis 5.50 ±2.69,Codonopsis 13.57 ± 6.80.The amount of drug use frequency,Licorice30 g,12g,15 g,10g,Pinellia10 g,9g,30 g,ginger 10 g,6g,Scutellaria10 g,12g,9g,Coptischinensis 3g,6g,dangshen15 g,10g,12 g,can provide reference for the clinical common dose.Fourth,Attending disease: Gancao Xiexin Tang can indicate a wide range of clinical multidisciplinary disease.Chinese medicine syndrome give priority to spleen and stomach syndrome,oral disease and Fox-Puzzle Syndrome.Western medicine give priority to Digestive diseases,Oral diseases,Immune system diseases,such as chronic gastritis,gastroenteritis,recurrent oral ulcers,Behcet’s syndrome.In addition,it is used in skin diseases,gynecological diseases.4 Conclusion:The theory of Acrid Openning and Bitter Descending and Sweet Coordinating is one of Zhang Zhongjing classic law.It is concentrated in the reflected of Gancao Xiexin Tang.The pathogenesis of Gancao Xiexin Tang is deficiency of the spleen and stomach,hot and humid intrinsic,intertwist of cold with heat,confliction between vital-qi and pathogens.Therapeutic method is acrid Openning and bitter Descending and sweet coordinating,strengthening Healthy Qi,clearing heat and removing dampness.Through the application of licorice Xiexin Decoction,it is found that the indications are widely used and still effectively instructor clinical in modern times.Modern clinical practice constantly expand the understanding and application of this prescription based on the inheritance of Zhang Zhongjing original thinking.Ancient prescriptions can still treat modern diseases.