Correlation Between Unbalance Of T Cell Subsets In Peripheral Blood And Curative Effect Of Sudden Deafness

Objective: Objective to investigate the correlation between peripheral blood T cell subset imbalance and sudden deafness by measuring the T lymphocyte subsets of peripheral blood in patients with sudden deafness,and to explore the influence of immune factors on the efficacy of sudden deafness.Methods:This study collected the patients with sudden deafness hospitalized in the otolaryngology surgery from June 2016 to January 2018 as an experimental group.The cases were selected and treated in accordance with the guidelines for the diagnosis and treatment of sudden deafness(2015).The patients with vocal polyps and nasal septum deviation were randomly selected as the control group(excluding the standard and sudden deafness group),according to the voluntary principle,and signed informed consent.Patients(including the experimental group and the control group)received peripheral blood before admission,and peripheral blood T lymphocyte subsets were detected.Hearing tests were performed before and after treatment,and duration,main symptoms,accompanying symptoms and prognosis were recorded.According to the normal or not of CD4+ and CD8+ in the T cell subgroup,it was divided into two groups,and the differences in the efficiency of the peripheral T cell subgroup imbalance group and the peripheral blood T cell subgroup were compared.The T cell subgroup imbalance group was subdivided into CD4+ abnormality and CD8+ abnormality,CD4+ abnormality,CD8+ normal,CD8+ abnormality and CD4+ normal,and the difference of the efficiency of each group was compared.Different.Results:(1)This study collected 105 patients with sudden deafness and 105 healthy controls.In the abdomen group,there were 47 male patients,accounting for 44.76% of the total,and 58 female patients,accounting for 55.24% of the total.There were 100 cases of monaural,5 cases of binaural and a total of 110 ears.The youngest is 16 years old,the oldest is 82 years old,and the average age is 49.6±15.1.The main onset age is between 50-60 years old.The onset time varies from 7 hours to 30 days,and the average onset time is 4±1.4.There were 50 males and 55 females in the healthy control group,with an average age of 48.7±13.2.(2)The values of CD+3,CD+4,CD+8,and CD+4/CD+8 were compared between sudden deafness and healthy controls.The experimental groups were: 68.43±9.91,37.83±5.16,25.43±5.47,1.62 ±0.66;control group: 70.21±3.29,39.54±2.57,26.69±1.92,1.51±0.15.Compared with the healthy control group,CD+3 cells,CD+4 cells,and CD+8 cells in patients with sudden deafness were reduced to varying degrees,and there was a statistically significant difference between the two groups(P<0.05);CD+4/ The CD+8 ratio increased(P<0.05).(3)All cases were divided into two groups according to whether the CD+4 and CD+8 in peripheral blood T cell subsets were normal,that is,there were 70 unbalanced T cell subsets in peripheral blood,the effective rate was 62.9%,and peripheral blood T cell subsets were normal 35 people,the effective rate is 82.9%.There was a statistically significant difference between the two groups(P<0.05).Patients with sudden deafness can be subdivided into subpopulations of T-cells: abnormal CD+4 and abnormal CD+8,abnormal CD+4,normal CD+8,abnormal CD+8,and normal CD+4.Compare the differences in efficiency between groups.SPSS analysis: ?2=0.994,P=0.658,P>0.05,a=0.05,the difference was not statistically significant.Conclusion: Patients with sudden deafness have an imbalance of T-cell subsets in the peripheral blood.There is a correlation between T-cell subsets in the peripheral blood and the incidence of sudden deafness.