| Objective Myocardial ischemia reperfusion injury(MIRI)is a serious complication of acute myocardial infarction(AMI)It has a serious adverse effect on the prognosis of patients.The intervention protection of MIRI has become a hot topic in clinical research.Panax notoginseng saponins(PNS)are effective components extracted from Sanqi,a Chinese traditional medicine.Pharmacological studies have confirmed that PNS can remove blood stasis and activate meridian,which can inhibit platelet aggregation,improve microcirculation and regulate blood lipids,and is widely used to treat ischemic disease of heart head blood-vessel in clinic.But there is no clinical report on whether PNS have protective effect on MIRI.This study aims to observe the effects of PNS on cardiac function index and inflammation index in patients with AMI after PCI,investigate the protective effects of PNS on myocardial injury and its mechanism,and provide a reliable basis for the clinical intervention of PNS on MIRI in patients with AMI after PCI.Method A total of 63 patients with AMI who were received emergencyPCI in the Department of Cardiology,Wuhan General Hospital of Chinese People's Liberation Army from January 2017 to December 2017 were selected as the study subjects.All of 63 patients were randomly divided into treatment group(33 cases)and control group(30 cases)according to the random number table.There were not significant differences of general clinical datas(Such as,the age,sex,smoking history,body mass index,combined hypertension,hyperlipidemia,diabetes,and the onset time of AMI)between two groups(P>0.05)Both groups of patients were received emergency PCI in the catheterization room of our hospital who were given conventional medical treatement of dual antiplatelet aggregation,lipid-stable plaque stabilization,anti-ischemic myocardial ischemia and other medications.The treatment group was supplemented with xueshuantong injection(0.5g,diluted with 5% glucose injection,250 ml,intravenous injection,once daily,for 10 consecutive days)The levels of serum SOD,IL-6,CK,CK-MB,c Tn T,and NT-pro BNP were measured in all of patients before and after PCI.Twelve lead electrocardiograms were performed in order to estimate infarct area by electrocardiogram QRS wave score method before and after PCI.LVEF,LVEDD were detected by echocardiography to assesse the left ventricular function before and after PCI.Also the relief of clinical symptoms,such as the number of episodes and duration of angina pectoris were observed during the first month after PCI.Result 1.The serum levels of CK,CK-MB,c Tn Tand NT-pro BNP after PCI in both groups were lower than those before PCI,and the levels of CK,CK-MB,c Tn T,NT-pro BNP in treatment group were lower than that in control group.There were significant differences between two groups(P < 0.01,P < 0.05).2.The examination of electrocardiogram showed that the infarct areas were comparable in both groups before PCI,but there was different in the level of recovery after PCI,which the level of recovery in the treatment group was better than that in the control group.There were significant differences between two groups(P<0.05).3.The left ventricular function were improved in different degrees in both groups after PCI,and there were significant differences between two groups(P<0.05).4.The serum SOD showed a first decrease,followed by a rise in the two groups after PCI,and SOD level in the treatment group was higher than that in the control group at each time after PCI.There were significant differences between two groups(P<0.01,P<0.05).5.The serum IL-6 showed a first rise,followed by a decrease in the two groups after PCI,and IL-6 levels in the treatment group were lower than those in the control group at each detection time after PCI.There were significant differences between two groups(P<0.01,P<0.05).6.The total clinical effective rate in the treatment group was higher than that in the control group after PCI,There were significant differences between two groups(P<0.05).Conclusion 1.The PNS can reduced the serum levels of CK,CK-MB,c Tn T,NT-pro BNP and the area of myocardial infarct,improved left ventricular function,which has the effect of reducing myocardial necrosis and protecting heart function in AMI patients after PCI.2.The PNS can increased the serum level of SOD in AMI patients after PCI,which is suggestd that PNS may protect myocardial injury by antioxidant stress response.3.The PNS can reduced the serum level of IL-6 in AMI patients after PCI,which is suggestd that PNS may protect myocardial injury by anti inflammatory response.The PNS can relieve the symptoms of myocardial ischemia in AMI patients after PCI. |
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