Clinical Observation On Treatment For Liver-Depression-Type Infertility With Pituitary Prolactin Adenoma By Shuganzhongzi Decoction Combined With Bromocriptine

Objective:To observe the clinical curative effect of Shuganzhongzi Decoction combined with bromocriptine dealing with liver-depression-type infertility with pituitary prolactin adenoma,and to evaluate drug safety,and to optimize therapy of liver-depression-type infertility with pituitary prolactin adenoma.Methods:60 patients with liver-depression-type infertility with pituitary prolactin adenoma were collected.And they were randomly divided into Treatment Group and Control Group by the clinic sequence.There were 30 patients for each group.The Treatment Group was treated with Shuganzhongzi Decoction combined with bromocriptine,while the Control Group was treated with bromocriptine only.We followed up patients and filled in the clinical observation table.Menstrual conditions,patients,prolactin(PRL)levels,pituitary prolactin adenoma size,pregnancy outcomes,and related clinical symptoms were recorded.statistical analysis was proposed to evaluated the clinical curative effect of Shuganzhongzi Decoction combined with bromocriptine dealing with liver-depression-type infertility with pituitary prolactin adenoma.Results:1.There was no statistically significant difference in age,TCM symptom score,PRL level and pituitary prolactin adenoma size between the two groups before treatment(P>0.05).2.The total effective rate of the two groups after treatment:The total effective rate in the treatment group was 80.0%.The total effective rate in the control group was 63.3%.There was statistically significant difference between the two groups(P<0.05).3.Comparison of menstruation after treatmet:The menstrual cycle and the amount of menstruation in treatment group became better than that in control group.The difference between two groups was statistically significant(P<0.05).4.The decline in serum prolactin levels during treatment:Serum prolactin levels in the two groups,which were detected when drug therapy went on for 1 month,2 months and 3 months,both declined significantly.There was no significant difference between two groups in the first month of treatment(P>0.05).After 2 months and 3 months,the difference was statistically significant(P<0.05).5.Comparison of pregnancy in the two groups:In the treatment group,there were 2 pregnancies in the treatment group and 4 pregnancies in the follow-up period.In the control group,there were 0 pregnancies and 2 pregnancies during follow-up,and the number of patients cured in the treatment group was higher than that in the control group.6.Changes in pituitary prolactinoma size after treatment:The volume(diameter)of pituitary prolactinoma in the treated group decreased more than that in the control group(P<0.05).7.Comparison of TCM syndromes before and after treatment in the two groups:The curative effect of the Treatment Group is better than that of Control Group,and comparison difference between groups was statistically significant(P<0.05).8.Comparison of adverse reactions during treatment:In terms of fatigue and constipation,the treatment group had fewer cases than the control group,and the difference was statistically significant(P<0.05).9.Safety analysis:During treatment,the bloods,urines,fecal routines,liver and kidney functions,ECGs of patients in both two groups were normal,and the treatment methods of both two groups were safe.Conclusion:The results of the study show that therapy of Shuganzhongzi Decoction combined with bromocriptine was better than bromocriptine alone in dealing with liver-depression-type infertility with pituitary prolactin adenoma.Combined medication got a better outcome of tumor inhibition,prolactin(PRL)level,menstrual conditions and pregnancy.Moreover,therapy of Shuganzhongzi Decoction Combined with bromocriptine depressed the tolerance,adverse reactions and the recurrence rate,which were prevalent in therapy of bromocriptine alone.