The Clinical Study On Treatment Of Septic Gastrointestinal Dysfunction With Gastrointestinal Fuyuan Therapy

ObjectivesGastrointestinal dysfunction is one of the common complications of sepsis.It is also an important factor to aggravate or induce the development of multiple organ dysfunction syndrome(MODS).Active treatment of gastrointestinal dysfunction is important for the prognosis of sepsis.In recent years,the role of traditional Chinese medicine in the prevention and treatment of septic gastrointestinal dysfunction has been receiving much more attention.Scholars have been exploring effective intervention measures in order to improve the gastrointestinal function impairment caused by sepsis.This research,based on.the theories of Professor Wei Beihai's Gastrointestinal Fuyuan Therapy,uses prospective,randomized control study method to observe the outcome of gastrointestinal reconstruction in the treatment of septic gastrointestinal dysfunction and discuss the clinical curative effect,from multi-angle observation of severity score,gastrointestinal function index and inflammatory index.MethodsThis study included 34 cases of gastrointestinal dysfunction of sepsis patients,from the ICU of Guang'anmen Hospital Affiliated to Chinese Academy of traditional Chinese Medicine.The study period is from September 1st,2017 to December 31st,2017.All the patients are randomly divided into treatment group and control group according to a study plan set by the inclusion and exclusion criteria.The control group was only given western medicine intervention,while treatment group on the basis of western medicine treatment combined with gastrointestinal Fuyuan decoction and rhubarb and mirabilite enema treatment.The course is set for 7 days.The first step is to get the basic information of the two group patients,including name,gender,underlying diseases.During the study,some scores and laboratory indicators will be recorded before and after the treatment,i.e.APACHE ? score,SOFA score,stomach intestine dysfunction score,white blood cell(WBC),C reactive protein(CRP),procalcitonin(PCT)and abdominal circumference,intra-abdominal pressure,frequency of the bowel sound,fecal occult blood test,28-day mortality rate and hospitalization days.All the data and statistics will be analyzed by SPSS 22 software.The test level is defined as 0.05,which means P<0.05 is considered statistically significant.Results1 There are no significant differences between the patients of two groups in age,gender,disease and APACHE ? score,SOFA score,WBC,CRP,PCT,gastrointestinal dysfunction score,the number of bowel sounds,abdominal circumference,intra-abdominal pressure,fecal occult blood before the test(P>0.05).All the baseline data is comparable.2 The 28-day mortality rate of the treatment group decreased,but it has no statistical significance compared with the control group(P>0.05).There is no significant difference in the hospitalization days between the two groups(P>0.05).3 Two groups of patients' APACHE ?,SOFA score,WBC,CRP,PCT,intra abdominal pressure all decreased after the treatment,compared with the level before the treatment.The results are statistically significant(P<0.05).The treatment group decreased significantly higher than the control group,with statistical significance(P<0.05).4 The treatment group's gastrointestinal dysfunction score,abdominal circumference decreased with the number of bowel sounds increased compared with the former level before the treatment.The results are statistically significant(P<0.05).The result of control group is not statistically significant before and after treatment(P>0.05).The comparison between two groups are statistically significant(P<0.05).5 There is significant difference between the two groups of the rate of occult stool blood test after the treatment(P<0.05).Conclusions1 Gastrointestinal Fuyuan Therapy combined with western medicine treatment can improve the severity of patients with sepsis-related gastrointestinal dysfunction.2 Gastrointestinal Fuyuan Therapy can inhibit inflammatory reaction and promote gastrointestinal motility recovery,reduce intra-abdominal pressure and gastrointestinal dysfunction score,help recover gastrointestinal mucosal bleeding injury.