Therapeutic Effect Of Shugan Liqi Combined With Western Medicine On Hepatic-gastric Disharmony Peptic Ulcer Disease

Purpose: Treat peptic disharmony with chaihushugansan and pantoprazole, amoxicillin, clarithromycin tablet,observing clinical symptoms and signs, Hp eradication rate and affect the performance of endoscopic, to provide clinical evidence for Integrative treatment of peptic ulcer. Material and method: Methods: Include 50 inpatients met the inclusion criteria in the First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from December 2013 to December 2014, they were randomly divided into treatment group and control group, 25 cases in each group. The control group were given 0.9% sodium chloride injection 100 ml, injection pantoprazole 80 mg, twice daily intravenous; amoxicillin l.Og, 2 times a day orally, clarithromycin tablet 0.5g, 2 times a day orally. After 10 days of continuous treatment, continue with 0.9% sodium chloride injection 100 ml, injection pantoprazole 80 mg, twice a day static point. The total course of four weeks. In the control group, the treatment group therapy based on the use of traditional Chinese medicine decoction chaihushugansan(medicine provided by the First Affiliated Hospital of Liaoning College of Traditional Chinese Medicine Council) 100 ml orally three times a day, before meals, the total course of four weeks. All patients before and after treatment were collected and recorded four diagnostic information, underwent endoscopy electronic 13C- urea breath test to check and record the results before treatment and four weeks after treatment. Data using SPSS17.0 statistical software for statistical analysis.Results:(1) after 4 weeks of treatment, in terms of the efficacy of TCM syndrome, the difference about the total efficiency between treatment group and control group has no statistically significant(P <0.05). there was a statistically significant on TCM syndrome score in terms of changes in the two groups after treatment symptom score comparison(P <0.05).(2) Hp eradication rate between the two groups: After four weeks of treatment after the review of 13C- urea breath test, the treatment group Hp-negative 23 cases, 2 cases of positive, Hp eradication rate was 92%; in control group, 20 cases of Hp-negative, positive 5 cases, Hp eradication rate was 80%. Hp eradication rate between the two groups, the difference was not statistically significant(P> 0.05).(3) The efficacy of endoscopic treatment group were clinically cured 13 cases, effective in 7 cases, 4 effect cases, one case;in control group, eight cases of clinical cure, significantly effective in 10 cases, effective 1 case, 6 cases ineffective. Treatment group, the total efficiency of 96% higher than 76%, the difference was statistically significant(P <0. 05). Conclusion: Treatment group in improving clinical symptoms of peptic ulcer patients, relieve epigastric pain, promote ulcer healing and eradication of Hp were better than the control group. Mechanism chaihushugansan treatment of peptic ulcer may be related inflammatory, inhibiting the growth of Hp, protect the stomach and duodenal mucosa, promote gastrointestinal motility and enhance immune function related to defense, worthy of further study and clinical application.