| Purpose: To explore the relationship between PTEN, NDRG1 and clinical pathological characteristics of endometrial carcinoma and its significance through studying the expression of PTEN and NDRG1 in endometrial carcinoma, atypical hyperplasia endometrium and normal endometrial tissue.Method: Collect surgical cases from 2009 January to 2015 December in Luzhong Hospital of Peking University Medical: endometrial carcinoma in 57 cases, endometrial atypical hyperplasia in 35 cases, normal endometrium in 31 cases, all of the above cases are confirmed by pathology postoperative, clinical and pathological data are complete, all of them aren’t treated by sex hormone therapy, chemotherapy and radiotherapy before operation. The expression of PTEN and NDRG1 in endometrial tissue is detected by immunohistochemical SP method, and analyzed the difference of the expression between them in different clinicopathological features of endometrial carcinoma(whether menopause, pathological type, degree of differentiation, depth of invasion, lymph node metastasis, surgical pathologic stage).Results: 1.The positive expression rates of PTEN in endometrial carcinoma, atypical endometrial hyperplasia and normal endometrium tissues are respectively15.8%, 65.7%, 87.1%, show an increasing trend. The positive expression rates of NDRG1 are 84.2%, 40% and 19.4%, respectively, which show a decreasing trend. 2.The positive expression of PTEN in different clinicopathological features of endometrial carcinoma is related to the degree of tissue differentiation, lymph node metastasis, surgical pathologic staging; the positive expression of NDRG1 is related to the degree of tissue differentiation, depth of muscular invasion and lymph node metastasis.Conclusion: The positive expression of PTEN in endometrial carcinoma, atypical endometrial hyperplasia and normal endometrium tissues show an increasing trend, the positive expression rate of NDRG1 show a decreasing trend, and they show a negative correlation. They may play a role in the occurrence and development of endometrial carcinoma to some extent. |
