Correlation Between TCM Syndrome Types And Laboratory Indicators Of Diabetic Nephropathy

Objective: By comparing the distribution of different TCM syndromes in patients with diabetic nephropathy,the differences between the general information of TCM syndromes and the correlation between TCM syndromes and laboratory indicators provide a scientific and objective reference for TCM syndrome differentiation of diabetic nephropathy Based on the prevention and treatment of diabetic nephropathy to provide some clinical ideas.Materials and Methods: 1.By retrospective analysis,300 patients with diabetic nephropathy were enrolled in Department of Endocrinology,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from March 2016 to November 2016.Among them,212 cases were included in the inclusion criteria and 88 cases were excluded.2.General information on patients: age,sex,body mass index(BMI),waist circumference(WC);Renal function related indicators:serum creatinine(Scr),blood urea nitrogen(BUN),uric acid(UA),Urine microalbumin(MALB),?2-microglobulin(?2-MG);Blood lipid-related indicators:Low density lipoprotein(LDL-C),Triglyceride(TG);Blood glucose related indicators:glucose(GLU),Glycosylated hemoglobin(Hb A1c),Fasting C peptide(C-PO).3.Using Excel to establish the database,SPSS 20.0 software for data analysis.Results: 1.DKD patients a total of 212 cases,of which 128 cases of qi and yin deficiency,constitute 60.38%;spleen deficiency dampness syndrome in 50 cases,constitute 23.58%;yin and yang deficiency in 34 cases,constitute 16.04%.2.The ratio of male to female in DKD patients was 1.3: 1,but there was no significant difference between the two groups(P>0.05).There was no significant difference between the two groups.3.The BMI and WC of the Spleen Deficiency Syndrome were higher than those of the other two groups.Compared with Spleen Deficiency and Dampness Syndrome,the difference of BMI and WC between Qi and Yin Deficiency Syndrome was statistically significant(P<0.01).The difference of BMI and WC between the two groups was statistically significant(P<0.05).There was no statistically significant difference between the two groups.The ?2 test showed that the composition ratio of overweight group and obese group was statistically significant(P<0.05).4.DKD syndrome between the Scr,BUN and UA differences in statistical significance were significant(P<0.01).Comparison of yin and yang deficiency: qi and yin deficiency syndrome and spleen deficiency syndrome Scr statistically significant(P <0.01).Compared with Spleen Deficiency and Dampness Syndrome: The difference of BUN between Scr,BUN,UA and yin and yang deficiency was significant(P<0.05).There was no statistically significant difference between the two groups(P>0.05).5.MALB and ?2-MG were statistically significant in the differences between the syndromes(P<0.01).Compared with the deficiency of yin and yang,the difference between the two indexes was significant(P <0.01).Compared with Spleen Deficiency Syndrome: MALB was significantly statistically significant(P<0.01),There was no statistically significant difference between the two groups(P>0.05).6.LDL-C and TG in the syndrome between the comparison were not statistically significant(P>0.05).7.GLU,Hb A1 c and C-PO were not statistically significant between the syndromes(P>0.05).8.212 cases of DKD patients,stage 156 cases,36 cases,20 cases? ? ?.By rank sum test,TCM syndromes and clinical staging are consistent(P<0.01).Comparison of Qi and Yin Deficiency Syndrome and Phase ?and Yin and Yang Deficiency and Contrast: Consistency was statistically significant(P<0.01).Spleen deficiency dampness syndrome compared with each period: do not have consistency(P>0.05).By Ridit analysis,R value of Qi and Yin Deficiency < R value of Spleen deficiency syndrome < R value of yin and yang deficiency syndrome.Conclusion: 1.In this study,the incidence of DKD patients was higher in men than in men,high incidence of age 60-69 years old.2.Overweight and obesity distribution mainly to spleen deficiency syndrome is more common,is the development of DKD risk factors.3.Blood creatinine,elevated urea nitrogen suggest that TCM syndrome may be from qi and yin deficiency to the direction of development of yin and yang;Blood uric acid is a risk factor for DKD,but also the pathological product of DKD.4.Urinary microalbumin and urinary ?2 microglobulin increased with the evolution of syndromes,Its evolution trend has a certain role in the syndrome differentiation,so MALB and ?2-MG as the objective basis of TCM syndrome differentiation is likely.5.TCM syndrome type may be Qi and Yin Deficiency Syndrome-Spleen Deficiency Dampness Syndrome-Yin and Yang Deficiency Syndrome for the evolution of the law;TCM syndromes and DKD clinical period there is a certain correlation,This study shows the Qi and Yin Deficiency and ?are consistent;yin and yang deficiency and are? consistent.