MRI Quantitative Parameters Were Used To Assess The Activity Of Intestinal Crohn's Disease (DCE-MRI And DW-MRI Studies)

Objective:To explore the value of MRI quantitative parameters including ADC and volume transfer constant(Ktrans)in assessment of the severity of crohn's disease.Methods:From June 2014 to January 2016,fifty patients with CD(only one lesion,and located in the ileocecal)were recruited,and all subjects underwent bowel examination with conventional MRI,diffusion weighted MRI(DW-MRI)and dynamic contrast-enhanced MRI(DCE-MRI)sequences.The quantitative parameters of each subject(ADC,Ktrans)and clinical data[Harvey-Bradshow index(HBI),C-reactive protein(CRP)]were collected.According the HBI,all CD patients were divided into three groups such as severe group,mild-moderate group,and static group.The differences otrans and ADC among the three groups were compared.The correlation between quantitative parameters of MRI(ADC,Ktrans and clinical data(HBI,CRP)were evaluated.Results:Fifty patients with CD were classified into three groups:static group(n ?16),mild-moderate active group(n = 21)and severe group(n = 13).The difference of Ktrans or ADC values among the three groups was statistically significant(P<0,05).There was significant difference between Ktrans or ADC values of any two groups(P<0.05).There was a positive correlation between Ktrans and HBI(r = 0.635,P<0.001),and CRP(r = 0.764,P<0.001);ADC value was negatively correlated with HBI(r =-0.614,P<0.001),with CRP(r =-0.490,P<0.001).There was a positive correlation between HBI and CRP(r = 0.755,P<0.001).Ktrans was negatively correlated with ADC(r?-0.348,P= 0.013).Conclusion:Quantitative parameters of MRI(Ktrans and ADC)are contributed to assess the severity of CD,and Ktrans is more sensitive and stability.