Nonlinear Analysis And Steady-state Optimization Of Continuous Bio-dissimilation Process Of Glycerol

Glycerol biotransformation into 1,3-propanediol has advantages such as renewable materials,mild reaction conditions,less by-products,and less environmental pollution.So,glycerol has become a biochemical process of concern.Therefore,the establishment and use of the optimization model and optimization method adapted to the process has a guiding role for the actual production of 1,3-propanediol.In this paper,the nonlinear analysis and steady state optimization of the continuous biological disproportionation of glycerol are mainly studied.Aiming at these problems,the nonlinear analysis results of equilibrium point calculation and stability analysis under different operation conditions are given.A steady state optimization model suitable for its process is established,and the optimization method is used to solve it.The main contents of the paper and the main results are as follows:1.For the disproportionation of 1,3-biological glycerol propylene glycol in the process of excessive dynamic system,a steady state optimization model to maximize the yield of 1,3-biological as the optimization objective,the stability requirements as constraint conditions,and to solve the model,finally,the optimal stable operating conditions for the biological disproportionation of glycerol and the maximum yield of 1,3-propanediol were obtained.2.Aiming at glycerol biologic disproportionation into 1,3-propanediol process reduction pathway,enzyme catalyzed nonlinear dynamic system.First,it carries out the nonlinear analysis of equilibrium point calculation and equilibrium point discrimination,and gives the specific analysis results;then,a steady-state optimization model with the maximum yield of 1,3-propanediol as the optimization objective and the stability requirement as the constraint condition was established.The optimal operation conditions of the glycerol biologic disproportionation process and the maximum yield of 1,3-propanediol were obtained.The results show that,compared with the existing literature,this paper not only makes the system stable,but also obtains the maximum yield of 1,3-propanediol.This provides guidance for the actual production process of 1,3-propanediol.