Study On Arteriosclerosis And Exercise Intervention Effects Of Methamphetamine Male Users

Objective:Men who are abstaining from drug addiction are trained for six weeks.They have abused methamphetamine before.We observed changes in plasma inflammatory factors and endothelial cell injury related factors levels before and after exercise intervention and explored the effects of this change on vascular occlusion and vascular elasticity in addicts.It provides a theoretical support basis for exercise to improve the vascular status of addicted persons and reduce the pathological development of vascular patients in addicted patients.Methods:The subjects were men who had abused methamphetamine and were abstaining from drug addiction at the Baini Lake,Hunan Province.We considered their physical health and randomly selected 40 people in 80 people as exercise groups for exercise intervention,and the rest as a control group.Exercise for six weeks,5 days a week,1 hour a day.The main mode of exercise is aerobic exercise combined with anti-resistance training.During the exercise,polar v800 is used to monitor the heart rate in real time to ensure that the exercise reaches the specified intensity.Before and after exercise intervention,Omron Colin-automatic arteriosclerosis detector was used to measure and collect the indicators,and blood samples were collected at the same time.Plasma IL-6,TNF-?,ICAM-1,ET-1 and Hcy concentrations were determined byELISA.Results:(1)After six weeks of exercise,the RbDP,RaDP;LbDP and LaDP decreased significantly in exercise group(p<0.05;p<0.01);The RABI and LABI increased significantly(p<0.01);The RbaPWV and LbaPWV decreased significantly(p<0.05,p<0.01);No significant changes in the control group(p>0.05);(2)plasma IL-6 and TNF-?increased significantly in exercise group(p<0.01),ICAM-1 decreased significantly(p<0.05);plasma ET-1 and Hcy decreased in exercise group(p<0.01),and No significant changes in the control group(p>0.05);(3)Before intervention,RABI was negatively correlated with drug use time(r=-0.388).After exercise intervention,RABI was positively correlated with IL-6 level(r=0.590),and negatively correlated with BF% and ET-1(r=-0.400;r=-0.473);RbaPWV and LbaPWV were positively correlated with age before exercise intervention(r=0.451;r=0.423).RbaPWV and LbaPWV were positively correlated with ET-1,Hcy and ICAM-1 after exercise intervention(r=0.519;r=0.490,r=0.417;r-0.404,r=0.535;r=0.514);Conclusions:(1)Exercise can significantly reduce the systolic and diastolic blood pressure of the limbs of the MA users,improve the ABI level,and improve the vascular occlusion and stenosis of the lower extremities.The mechanism may be related to exercise,which can significantly increase the level of myogenic IL-6 in MA users,decreasethe level of ICAM-1 and Hcy,and reduce the inflammatory response caused by excessive Hcy levels.(2)Exercise can reduce the baPWV of the MA user,increase the vascular tension,increase the elasticity of the aortic blood vessels,and reduce the possibility of pathological development of arteriosclerosis in the MA users.The mechanism may be related to exercise that can reduce the level of ET-1 in the blood of MA users and reduce the damage of vascular endothelium.