Study On The Preparation And Quality Standard Of Pyrrosia Leaf Formula Granules

Pyrrosia leaf belongs to Pyrrosia sheareri(Bak.)Ching ? Pyrrosia lingua(Thunb.)Farwell or Pyrrosia Petiolosa(Christ)Ching.The dried leaf has been commonly used in the treatment of relieve stranguria by dieresis,clear lung and disperse sputum,cool the blood to stop bleeding.In our country,Pyrrosia has abound resources,which has been used for thousands of years.Pyrrosia is one of the most important traditional Chinese medicine.Chinese medicine formula granules are made from high quality herbal slices with modern pharmaceutical technology under the guidance of Traditional Chinese Medicine theory,which has the characteristics of convenience,safety and health.The main contents include:1)?Ten kinds of Pyrrosia leaf were collected in different fields.In the medicine quality standard study,according to the Chinese pharmacopoeia 2015 edition a Herba plantaginis item,to the identification,inspection and content determination in the detection.The HPLC fingerprit method for quality control of Pyrrosia leaf was established,and methodolody was also researched.This method improving the quality standard of Pyrrosia leaf.Screening suitable of Pyrrosia leaf study on the process of next stage under the above results.2)?Taking the ratio of extraction,contents of chlorogenic acid and effective transfer rate as indexs,the paper uses the orthogonal test method to prepare Pyrrosia leaf formula granules.The results show that the best preparation of formula granules is adding 22 times water(the first added amount is 12 times,the second added amount is 10 times)and extracting 2 times for 1.0 hour respectively.At the same times,the production process was reasonable and feasible after pilot test.3)?The quality standard of Pyrrosia leaf formula granules was established,which was based on the systermatic research of the HPLC fingerprit method for quality control of Pyrrosia leaf formula granules,granularity,moisture content,dissolution,content determination in the detection.The established quality standard provides reference for the quality control of Pyrrosia leaf formula granules.4)?The stability of 3 batches,which includes influence factortest,accelerated test and long-term test was inspected according to the quality standard.The results shown that each project has no obvious change,and the Pyrrosia leaf formula granules is stable.