Synthesis Of Pyrimidine Phosphonate Catalyzed By Ni Catalyst Synthesis Of Fluorinated Hexahydrocyanide Catalyzed By PEG-OSO₃H Catalyst

Organic phosphine compounds containing carbon and phosphorus?C-P?bonds are widely used in optical materials,functional molecular materials,catalysis,pesticides,and pharmaceutical chemistry,and exhibit many excellent properties.How to construct this kind of compound by green and environmental protection method,especially to construct highly functional phosphonate and phosphine compound,has become the trend of organic phosphonite chemists in recent years.The organic fluorine compounds containing fluorinated?C-F?bonds are also widely used in pharmaceutical chemistry,biochemistry,surfactants and so on.And the polymer-supported compounds such as supported reagents,catalysts and scavengers have been developed rapidly in recent years.The synthesis of these compounds is still a hot topic.In this paper,the preparation of pyrimidine phosphonate compounds and the hexafluoropyrimidine derivatives were reviewed.The recent progress in the study of reactionscontainingC-Pcompoundswasreviewed.Theeffectsof2-chloro-pyrimidineanddifferentphosphonates,Andthereactionof three-component Biginelli-type hexahydropyrimidine derivatives was studied.The main contents and results are as follows:1.The reaction of 2-chloro-pyrimidine with pyrimidine phosphonates catalyzed by NiCl₂?dppf?was explored and the effects of different catalytic systems on the reaction substrate and phosphate ester compounds were discussed.A series of compounds containing carbon-phosphorus?C-P?bond frameworks have been developed,resulting in a novel and convenient method for the synthesis of phosphonic acid compounds.2.The hexahydropyrimidine derivatives were synthesized by catalyzing the three-component Biginelli reaction with polyethylene glycol-supported sulfuric acid?PEGOSO₃H?as catalyst.The influence of various factors such as the ratio of material in the reaction,the reaction time,the amount of catalyst and its dosage on the reaction was also investigated,and a variety of target products with electron donative or electron withdrawing substituents were obtained.PEG-OSO₃H,as a catalyst,is repeated in this process and has high reactivity and selectivity compared to other literature reports.The structure of the above target products was confirmed by ¹H NMR,¹³C NMR,³¹P NMR,¹⁹F NMR and HRMS.