Study On Preparation Technology And Quality Standard Of Mulberry Ziyin Granules

The liver and kidney are homologous,and the kidney yin is nourished,then the liver is stripped of strips,and the blood and blood are abundant,so that the water is prosperous and the blood is lost.The kidney essence and liver blood can nourish each other.This is a method for the treatment of the disease;Evacuation of wind and heat,Qingfei Runzao,Liver and eyesight,this is a method of treatment.The medicinal flavors of this side are compatible with each other,treating both the symptoms and the root cause,which has achieved the effect of nourishing yin and tonifying kidneys and boosting blood and producing fluid.The original recipe is a traditional decoction,which has a long decoction time,a relatively low degree of concentration,mildew,a short shelf life,inconvenience to carry,etc.and a large dose,poor taste and odor,poor patient compliance,and particles In addition to preserving the active ingredients of the original decoction agent,the agent also has the advantages of convenience for oral administration,convenient carrying,storage,and transportation.This article is based on the literature research on the extraction technology and pharmacological effects of the original herbal extract of the original ointment,combined with modern related technologies.Combine the original herbal medicines with alcohol extract and water extract,combine the extracts of the two extracts,add a certain amount of excipients,prepare wetgranulation,establish the quality standard of mulberry yin granules,and initially examine the The stability of the granules.Reaserch on preparation process: by looking at the preparation method of the related granules and related literatures in the 2015 edition of Pharmacopoeia,combined with the properties,pharmacologic effects and clinical application of the main ingredients of the herbs in mulberry zyin granules,the active ingredients of the herbs were extracted by star point design-response surface method.Taking total flavonoids content and total triterpenoid saponins content as the evaluation criteria,and total polysaccharides content as the index,the factors and levels affecting the content of the main active components in the prescription were investigated,and the optimal extraction process was optimized.The content of active components in the traditional extraction process and the optimal extraction process were compared and the extraction route was determined.By studying the molding process,the density,type and dosage of extract and the optimum preparation parameters were selected.Finally,the test results showed that the best process and determination method have a certain reference value.Preparation process study: by consulting the relevant granules and preparation methods of granules in the relevant literature included in the 2015 edition of the Pharmacopoeia,combined with the properties,pharmacological effects and clinical applications of the chemical components of the mulberry yin granules in the main role of the various herbs,this topic The star point design-response surface method was used to extract the active ingredients of the prescription Chinese medicinal materials.The total amount of total flavonoids and the total triterpene saponin content were used as the evaluation criteria.The total polysaccharide content was used as the index to evaluate the effect of the prescription.The factors and levels of the main active ingredient content are optimized for the optimum extraction process;and the active ingredientcontent of the conventional extraction process and the optimum optimum extraction process are compared to further determine the extraction process route.Through the research of the molding process,the concentration of the extracted extract,the type and amount of the auxiliary materials were examined,and the optimal preparation process parameters were optimized.Finally,the preparation process was verified,and the verification experiment showed that the best process and measurement method are feasible and have certain reference value.Quality standard research: In order to ensure the stability and controllability of the mulberry yin yin granules,a qualitative identification method was established for mulberry mulberry,mulberry mulberry,Eclipta,Ligustrum lucidum in mulberry yin granules by thin-layer chromatography.The content of rutin and ginsenosides in the mulberry yin-yin granules was determined by reversed-phase liquid chromatography with rutin and ginsenoside as the reference substance,and a methodological survey was conducted to fully establish the mulberry nourishing effect.Particle quality specification system.Stability test: preliminary stability test was performed on mulberry yin granules,and the characteristics of yam yin granules,qualitative identification of thin layers,determination of liquid phase content,and other physical and chemical indicators were performed every month from 0 to 3 months.The inspections and test results showed that all the inspection items were in compliance with the quality standards and the relevant requirements under the2015 “Chinese Pharmacopoeia”granule general rules,and the stability was good.This subject has conducted in-depth research on the extraction process and molding process of mulberry yin-yin particles,and established the quality specification of mulberry yin-yin granules.The stability of mulberry yin-yingranules has been initially investigated,which will be the development of mulberry yin granules in the future.The application provides experimental data.