Preparation,Properties And Applications Of Acid Anhydride Modified Cellulose Film Materials

In this paper,three different anhydrides?succinic anhydride,nitriloacetic acid anhydride,and citric anhydride?were used to esterify the hydroxyl groups at the C6position of microcrystalline cellulose?MCC?.With the catalysis of EDC and NHS,cellulose ester was further crosslinked L-glutamic acid by amidation reaction,and the film materials of MCC-SAD?MS??MCC-NTAA?MCN??MCC-CAD-GA were obtained through casting techmology respectively.The related characteristics of the modified cellulose membrane materials and its application in controlled drug release,removal of dyes and metal ions in aqueous solution were discussed in detail.The cellulose films material?MS?modified by SAD was used as a drug carrier for loading and controlled release of domperidone drug.The characterization methods such as FTIR,XRD,TG/DTG and SEM have jointly proved the success of modification and drug loading,also determined the structure of the modified membrane material and its hydrogen bonding interaction between cellulose films material and the drug.And the water absorption,mechanical properties,light-blocking properties,in vitro degradation of the modified cellulose membrane material were also investigated.The TGA/DTG curve showed that the thermal stability of the drug-loaded membrane sample was improved.The degradation data of the modified membrane material in lysozyme showed that the addition of SAD improves the anti-degradation behavior of the membrane material and prolonged its service life,which is favorable for its application in sustained release materials.In addition,the drug-loaded membrane material prolonged the release time of the drug domperidone,and the cumulative release rate of domperidone drugs decreased with the SAD content increased,and the release followed a super case type II transmission and a non-Fickian diffusion mechanism.This modified cellulose membrane material has profound implications for improving the bioavailability of drugs.Amino triacetic anhydride was used as modification reagent to modify the microcrystalline cellulose by esterification reaction.The modified cellulose membrane material MC?N was prepared and its adsorption performance to methylene blue dye was studied.FT-IR,XRD,EDX,elemental analysis and TG/DTG analysis methods verified the occurrence of esterification reaction between MCC and nitriloacetic anhydride.The investigation of the thermal stability,micro-morphology,mechanical properties,and swelling properties of the modified membrane material showed that the membrane material was a stable and environmentally friendly renewable material.Adsorption data at different times and pH indicated that the modified membrane material exhibited excellent adsorption capacity for methylene blue dyes,the membrane material could be reused at least five times,and the adsorption kinetics model showed that the overall rate of the adsorption process was controlled by the chemisorption process.In addition,the adsorption isotherm was in good agreement with the Langmuir model.This MC?N membrane material has a certain potential for application in removing dyes in aqueous solutions.Cellulose was esterified with citric anhydride,with the catalysis of EDC and NHS,L-glutamic acid was used as a cross-linking agent to react with cellulose ester through amidation reaction to obtain MCC-CAD-GA membrane material.The ability of the film to adsorb low concentration heavy metal ions(Cd²⁺,Co²⁺,Ni²⁺,Pb²⁺,and Cu²⁺ions)in water was investigated.The thermal stability,mechanical properties,and water absorption properties of the modified films were greatly improved,which provided conditions for its recycling.The optimal conditions were as follows:adsorption at room temperature for 2 h,pH 6 and adsorbent dosage was 10 mg.In addition,the adsorption behavior of the cross-linked membrane material to metal ions followed the pseudo-second-order kinetic model,and the adsorption isotherm was fitted with the description of the Langmuir model.The preparation of the modified cellulose ester film material broadened its application in the adsorption of metal ions.In summary,the modified cellulose membrane materials obtained in this paper are all safe,stable,non-toxic,environmentally friendly and biodegradable biofilms,which are applied in different fields because of their different properties.Due to its wide range of sources,biodegradability,biocompatibility,and environmental friendliness,cellulose waste can be completely decomposed by microorganisms in the environment.This is great significance for broadening its scope of application,meeting the environment-friendly concept and achieving sustainable development.