Preparation And Application Of Silver Hybrid Nanomaterials Based On Poly(Ether Amine) Containing Thiol Groups

Because of their surface effect,volume effect and quantum effect,hybrid nanomaterials are widely used in the fields of catalysis,fine chemical engineering,photoelectric materials and biomedicine.Silver nanoparticles have attracted extensive attention due to their good antibacterial and anticancer properties,but the agglomeration caused by their high surface energy limits their development in the field of biomedicine.To solve this problem,polymers are often used to stabilize and afford new functions to silver nanoparticles.The catalytic activity,antibacterial activity and anticancer activity of AgNPs are inherited by silver/polymer hybrid nanomaterials,and they also can disperse in many solvents.But the preparation of silver/polymer hybrid nanomaterials are often tedious.In the preparation process,the catalyst and reducing agent are necessary,and purification process is complicated,which is not in accordance with the requirements of green chemistry.In this work,multi-functional poly?ether amine??PEA?was mixed with the AgNO₃,then the silver hybrid nanoparticles were prepared by photochemical reduction.The characterization and properties of the hybrid nanomaterials were investigated,the main research contents were listed as follows:1.The hydrophilic poly?ether amine??SH-PEA?were synthesized with poly?ethylene glycol?diglycidyl ether?PEODE?and cysteamine?MEA?,and its characterization was studied.The Ag/SH-PEA hybrid nanoparticles were prepared with AgNO₃ and SH-PEA by photochemical reduction,and SH-PEA was the stabilizer and reductant.The preparation conditions of hybrid nanoparticles were investigated by changing the factors such as UV irradiation time,the concentration of SH-PEA and AgNO₃.The results showed that when the SH-PEA was 1 mg mL^-1,the AgNO₃ was 0.2 mg mL^-1,and the UV exposure time was 3 min,a Janus structure was formed.When the concentration of SH-PEA was 1 mg mL^-1,the concentration of AgNO₃ was 1 mg mL^-1,and the UV irradiation time was 3 min,an assembly structure was formed.2.The applications of Ag/SH-PEA hybrid nanomaterials were investigated.The results showed that both structures of Ag/SH-PEA nanoparticles could dispersed uniformly in water,DMF,DMSO,methanol and acetone.Methyl orange could be degraded by Ag/SH-PEA under irradiation,the degradation rate of methyl orange by Janus structure was 28.63%in 60 min,and the degradation rate by assembly structure run up to 72.99%in 60 min.Ag/SH-PEA could inhibit the growth of different bacteria.The antibacterial effect of the Janus structure on E.coil and S.aureus was better than that of the assembly structure.The cytotoxity results showed that the cell compatibility of Janus structure was more than 80%within 0.064mg mL^-1,which suggested its good biocompatibility.And the cell death rate of assembly structure was more than 80%within 0.016 mg mL^-1,which suggested its great cytotoxicity.3.The amphiphilic poly?ether amine??SH-aPEA?were synthesized with PEODE,poly?propylene glycol?diglycidyl ether?PPODE?,and MEA,and its characterization was studied.The silver/amphiphilic poly?ether amine??Ag/SH-aPEA?hybrid nanoparticles were prepared with AgNO₃ and SH-aPEA by photochemical reduction,and SH-aPEA was the stabilizer and reductant.The preparation conditions of hybrid nanoparticles were investigated by changing the factors such as UV irradiation time and the concentration of SH-aPEA.The results showed that SH-aPEA was thermol-responsive,and the transition point was in the ranged from 35 to 40?.When the SH-aPEA was 3 mg mL^-1,AgNO₃ was 1 mg mL^-1,and the UV irradiation time was 3 min,the needle structure of Ag/SH-aPEA was formed.4.The applications of Ag/SH-aPEA hybrid nanomaterials were investigated.The results showed that Ag/SH-aPEA could disperse uniformly in water,DMF,DMSO,methanol and THF.Methyl orange also could be degraded by Ag/SH-aPEA,the degradation rate of methyl orange by the needle structure was55.86%in 60 min.Ag/SH-aPEA could inhibit the growth of different bacteria,the antibacterial effect of the needle structure on E.coil was better than that on S.aureus and B.subtilis.