Synthesis,Bio-imaging And Tumor Therapy Effect Of Different Kinds Of Two Dimension Of Functional Nano-materials

In recent years,nanoparticles with the luminescence and magnetic property have gained much attention from researchers for using in multifunctional drug delivery systems,which provide anticancer drug,photo-thermal and photo-dynamic materials with in a single system.Rare earth luminescent materials show potential application in bio-labeling and bio-imaging due to the unique characteristics,such as physical and chemical stability,narrow emission bands,high luminescent purity,wide emission wavelength,large Stokes shift,and long lifetime.The main research content is list as below.A novel multifunctional composite was designed and prepared by integrating NaScF4:Yb/Er up-conversion nanoparticles?UCNPs?and black phosphorus sheets?BPS?for a single 980 nm laser light mediated photodynamic therapy.Hexagonal NaScF4:Yb/Er nanocrystals have been directly synthesized via a facile one-step hydrothermal route.The as-prepared nanocrystals were monodisperse and the novel NaScF₄:Yb/Er nanocrystals exhibited intrinsic intense red upconversion emission,in contrast to other lanthanide-doped fluoride nanocrystals.Remarkably,These water-soluble hexagonal NaScF4:Yb/Er nanocrystals with intense red emission are ideal for a variety of in vitro and in vivo biological imaging applications.UCNPs served as energy swtich were modified with poly?acrylic acid??PAA?,and the BPS were stabilized by the FA,then the two counterparts were integrated into UCNPs-BPS composite via electrostatic interaction.Under 980 nm NIR light irradiation,the composite exhibits excellent anti-tumor efficiency due to the generated large amount of reactive oxygen species?ROS?,which has been evidently confirmed by in vitro and in vivo results.A facile and mass production route was presented to fabricate Yb³⁺/Tm³⁺co-doped BiOBr nanosheets.Different from the complicated carrier combining photosensitizers?PSs?with up-conversion nanoparticles?UCNPs?,which generates PDT effect by fluorescence resonance energy transfer?FRET?process from UCNPs to PSs upon near-infrared light excitation,this as-synthesized material can be self-activated by deep-penetrated 980 nm laser to produce a large amount of reactive oxygen species?ROS?,giving rise to high PDT efficiency which has been proved by in vitro and in vivo therapeutic assay.Surface modification of the BiOBr:Yb,Tm nanosheets with polyethylene glycol?PEG?endows the system with improved biocompatibility.Combing the inherent fluorescence and CT imaging properties,an imaging monitored therapeutic system has been realized.The system overcomes the problem of low tissue penetration depth and complicated structure induced low efficiency and potential safety concern.Our finding presents the first demonstration of self-activated nanoplatform for targeting and noninvasive deep-cancer therapy.