Study On The Preparation Process And Quality Of Amlodipine Besylate/Atovastatin Calcium Tablet

Hypertension has become a major threat to human health and life of the disease,studies have shown that arteriosclerosis caused by arteriosclerosis is the cause of myocardial infarction,cerebrovascular and other diseases.And hypertension,dyslipidemia is endothelial dysfunction,arterial elasticity of one of the important causes of decline.Amlodipine besylate calcium is the first compound for the treatment of hypertension with hyperlipidemia at the same time containing two active ingredients for the treatment of different symptoms.According to the different solubility and stability of the two main drugs,this study used orthogonal experiments and other methods were on the amlodipine besylate atorvastatin calcium tablets prescription and process research,while the quality of the preparation of the study.According to the dissolution and stability of the experimental results to choose,and ultimately determine the amlodipine besylate/atorvastatin calcium tablets prescription:(10,000 pieces of feed)amlodipine besylate 69.3 5g,atorvastatin calcium 108.44g,calcium carbonate 100g,microcrystalline cellulose 588 g,pregelatinized starch 10g,Tween-80 5g,cross-linked sodium carboxymethyl cellulose 50g(additional),microcrystalline cellulose 50g(additional),Silicon dioxide 10g,Magnesium stearate 2.5g,2%hydroxypropylcellulose 50%ethanol solution 360 g,Opadry(?)85 F28751 100g,purified water 400g(made 20%coating solution).