The Study Of Material Surface Stereochemistry On Antibacterial Adhesion

Surface stereochemistry is a new type of antibacterial adhesion strategy.This strategy utilizes the "chiral preference" of bacteria so that bacteria do not adhere to the surface of the material.Starting from the borneol,a series of terpenoids and non-steroidal substances with different stereochemical structures were selected.We find the different response patterns of bacteria to different stereochemistry structures,so as to find a relationship between stereochemical structure and antibacterial adhesion.The substances selected here include L-borneol,D-borneol,menthol,5-norbornb-2-carbaldehyde(NC),1-adamantanol,and 1-adamantanecarbonyl chloride(AAC),etc.These substances were grafted onto PEI-modified base materials and the following results were obtained through the study of antimicrobial adhesion:1)There is a statistically significant difference in the antibacterial performance between surfaces(LFB and DFB)with different chiral structures;2)Antibacterial surface with asymmetrical stereochemistry structures are significantly better than those with symmetrical stereochemistry structures.3)The antibacterial surface antibacterial performance of the terpenoids with double ring structure is better than that of the teipenoids with single ring structure;4)Surface antibacterial properties with symmetric stereochemistry are not obvious.In addition,based on the extensive application of halogens in antibacterial medicines,we also selected a series of compounds which containing F,Cl,and Br.From the point of view of elements,we find the relationship between surfaces that contain different elements and antibacterial adhesion.The following results were obtained:From the perspective of stereochemical structure,the halogen elements located in the meta-position have better antibacterial properties than the ortho-position and para-position.