Free-standing Cu-based Metal-organic Frameworks Derived Materials As Non-enzymatic Glucose Sensors

In recent years,Diabetes mellitus has become one of the high incidence diseases in the world.In order to monitor the change of diabetes in time,it is very important to detect the changes of blood glucose regualrly every day.Therefore,development of efficient and reliable glucose sensors is an research area of great concern.Most of the commercial glucose meters are based on enzymatic glucose sensors.Due to enzymes are easily deactivated by environmental effects,the detecation results of these sensors are easily affected.So researches have been made to construct non-enzymatic glucose sensors based on noble metals,transition metals and carbon-based materials.In this paper,Cu-TCNQ grown on the surface of copper foam substrate were using for non-enzymatic glucose detection.It overcomes the problems of poor conductivity and easy collapse of traditional MOFs.The self supporting structure of Cu-TCNQ solves the problems of complex preparation of modified electrodes,easy falling off of electroactive materials and poor stability in traditional chemistry.A free-standing CuO working electrode with excellent performance was prepared by using Cu-BTC as the precursor.The main research results were expressed as follows:A free-standing Cu-TCNQ nanorod array electrode was prepared by using chemical bath at normal temperature.Then in order to enhance the stability of Cu-TCNQ,the electrode was sintered at 400 ℃ high temperature.The results showed that the sensitivity of the electrode was as high as 34.96 m A·m M^-1·cm^-2.The linear range was from 1 00 μmol·L^-1 to 3.20 mmol·L^-1.And after sintering,the linear range was widened to 5.17 mmol·L^-1.Low detection limit of 0.33 μmol·L^-1 were obtained.The electrode showed excellent specificity to glucose,attractive reproducibility,long-term stability and high tolerance to chloride ions.The results demonstrated the practicability in detecting human blood serum samples with appealing accuracy and precision.Cu-BTC was directly deposited on the surface of the foam copper by the constant-potential electrodeposition which using a three electrode system,then through several cyclic voltammetry turned into Cu O electrode,the electrode showed excellent property on non-enzymatic glucose sensing.A sensitivity of 27.69 m A·m M^-1·cm^-2,the linear range of 1.00 μmol·L^-1 to 5.40 mmol·L^-1 and the detection limit of 0.33 μmol·L^-1 were achieved.The electrode possesses not only excellent specificity to glucose,but also the attractive reproducibility,long-term stability and high tolerance to chloride ions.The similar results with the hospital test report were obtained in the detection of human blood serum samples,implying the application value of the electrode.