Study For The Fabrication Of Hierarchical Tubular Structured Micromotors For Biological Sensing

The long-term development and application of biological sensing put forward higher requirements for the detection sensitivity and accuracy,so how to achieve ultra-high sensitivity and accuracy of target molecular sensing has become an important direction for the research of biological sensing.Surface-enhanced Raman Scattering(SERS)spectroscopy is a powerful tool for the sensing of target molecules,which is very sensitive.However,its sensitivity and accuracy may be not satisfied in some real applications.Therefore,further increases of the detection sensitivity and accuracy of SERS is a promising research direction.For the application of SERS in biological sensing,recent research proofed that micro/-nanomotors can act as an effective collectors for automatic collection of target molecules,leading to the enhancement of SERS sensitivity.Based on this promising system,my synthesis will mainly be focused on the fabrication of a simple,low-cost and multi-functional hierarchically structured micro/nanomotors towards realizing much higher SERS sensitivity and accuracy.The main features of my synthesis are the rolling-up method of micro-/nanomotors and the building-up of hierarchical structures.We have succeeded in realizing the fabrication of hierarchical structured micro-/nanomotors without employing sacrificial layers,which could not only simplify the preparation steps of the micro-/nanomotors,but also minimize the possibility of structural and functional damage when removing sacrificial layers.The main works involved in my synthesis are shown as follows:1.Anodic aluminum oxide(AAO)templates were prepared by electrochemical anodization,and then in combination with nanoimprint technology to prepare nanostructured Al substrates.The cell sizes of periodic nano-cap or nano-bowl arrays on the Al substrates can be tuned by simply adjusting the anodizing voltage,and the surface morphologies of nanostructured Al substrates can also be tailored by adjusting the nanoimprint parameters;2.Rolling-up of hierarchical tubular structured micromotos can be realized by releasing the strained multilayers on the surface of imprinted nanostructured Al substrates.3.By adjusting the surface morphologies of imprinted nanostructured Al substrates,the hierarchical structures on the tubular micromotors can be effectively tuned.4.By adjusting the thicknesses of strained multilayers and the hard mask opening diameters,the diameters and lengths of hierarchical tubular structured micromotors can be controllably and effectively tuned,respectively.