Study On Preparation Technology And Quality Standard Of Taohongsiwutang Dripping Pills

Taohongsiwutang is one major prescription for menstruation regulation,and it is one prescription from Yizongjinjian,also known as flavored Siwutang,which is originally found in Yizongjinjian.This prescription consists of Siwutang as well as peach kernel and safflower,and achieves functions of nourishing blood.Modern research shows that Taohongsiwutang achieves effects of dilation of blood vessels,anti-inflammation,anti-fatigue,anti-shock,regulation of immune functions,lipid-lowering,micronutrient supplementation,and anti-allergy.Prescription of Taohongsiwutang includes Rehmannia of 15 grams,angelica of 15 grams,white peony root of 10 grams,Chuanxiong of 8 grams,peach kernel of 9 grams,saffron of 6 grams.Taohongsiwutang is basing on removing blood stasis,supplemented by nourishing blood and Qi.Peach kernel and safflower are two powerful components for removing blood stasis,which mainly helps blood circulation.Sweet warm Rehmannia and Angelica help nourishing liver and blood,as well as regulating menstruation.Root of herbaceous peony may nourish blood to enhance functions of blood.Chuan Xiong helps blood circulation and regulating blood and Qi.This prescription is properly composed with characteristics of removing blood stasis,producing new blood vessels,as well as smoothing Qi.Taohongsiwu dripping pills are prepared in accordance with principles of Chinese traditional medicine combining with modern technology,and their taste,meridian,efficacy are almost consistent with original Taohongsiwutang.Taohongsiwu dripping pills are also prepared in a new form by the principles of regulating preparations by symptoms as well as compound decoction.We optimize the particle preparation process of Siwutang in 10-20 every squre inch,percolator ethanol extraction 85%,the temperature is following 60? vacuum drying.drug mix matrix(PEG4000:PGE6000=3:1)and accordance with clinical is 2.4:1.dimethyl silicone 5? confusion grey.Chinese traditional medicine to 85?determine relevant technique parameters,and the distances 9-10(cm),and the speed is 40-50(d/min).Thin layer chromatography is adopted with paeoniflorin,angelica reference substance,chuanxiong,rehmannia,safflower and saffron peach reference substance as control to perform content determination(per gram of this product containing peony glycosides,no less than 6.354(mg/g).Meanwhile stability study is also performed,indicating that preparation process is feasible,and quality standard is both stable and controllable.Eventually our products are effective and stable with high safety.Our study systematically explores extraction technology,preparation molding technology,as well as quality standards on Taohongsiwu dripping pills,which provides sufficient pharmaceutical data for further approval and marketing.We determined preparation route,and establish draft of quality standard,meanwhile we performed 6-month acceleration and long-term stability observation on three batches of testing products.Our study reveals that preparation technique of Taohongsiwu dripping pills we determine is stable and feasible.Testing methods of all indexes for quality standard are proved to achieve good reproducibility and high stability,and can be adopted in quality control of Taohongsiwu dripping pills.12-month stability study primarily validates stability of our products,and follow-up stability investigation is still on-going.