Synthesis Of 1,8-naphthyridine Derivatives As A Fluorescence Probe For Amyloid-?

1,8-naphthyridine derivatives have the advantages of high fluorescence quantum yield and high molar extinction coefficient and excellent photochemical,photophysical properties and good coordination ability.After BF2 were introduced to get 1,8-naphthyridine fluoride boron compounds,its excellent fluorescence properties can be used as a fluorescent probes for ?-amyloid protein(A?).1.Synthesizing five novel 1,8-naphthyridine compounds(L1-L5),four novel(C1-C4)and one known(C5)1,8-naphthyridonium fluoroboron compounds.The UV absorption spectra and fluorescence emission spectra of nine novel compounds in two different solvents were examined.The results show that the nine compounds have a certain luminous ability,of which four new 1,8-naphthyridine fluoride boron compounds luminescent performance is more excellent.2.The crystal of 8 compounds was cultured and the crystal structure was determined by X-ray single crystal diffraction,and compared with the theoretical data.3.Using the theory of density functional theory,UV spectra were obtained by theoretical calculation,and the experimental spectra were compared with the experimental spectra.4.The protein titration experiment was carried out and it was found that the fluorescence enhancement of compound C3 could be used as a fluorescent probe for ?-amyloid protein(A?).