Preparation And Characterization Of 3D Printed Sodium Alginate/Bioactive Glass Porous Scaffold

In the field of bone tissue engineering,3D printing extrusion deposition technology has broad prospects.Bioactive glass is a bone repair material with great development and application prospects.Bioactive glass has the ability to induce bone formation,which allows bioactive glass to repair and replace infected or damaged bone tissue.ZnO has good biocompatibility and good biological activity,as a reinforcing phase to improve the mechanical and biological properties of the scaffold.Bioactive glass was prepared by sol-gel method,and SA/BG scaffold was prepared by 3D printing extrusion deposition technology.Scaffold of different aperture sizes are obtained by computer control of the wire pitch.Through the characterization and research of the physical and chemical properties and biological properties of the scaffold,it was found that the porous scaffold has better performance with a pore size of 400 ?m and a wire pitch of 1.2 mm.It provides a post-processing basis for the subsequent construction of porous supports with different ZnO contents.A series of scaffolds with different mass ratios of ZnO/BG were prepared by 3D printing extrusion deposition technology.SA as a crosslinking agent,and the pore size was controlled to 300-400?m.The pore structure,micromorphology,physical and chemical properties and in vitro antibacterial ability of the scaffold were characterized.It is found that the compressive strength of ZnO/BG scaffold is significantly improved with the increase of ZnO concentration.Different concentrations of ZnO/BG scaffolds have different degrees of inhibition on E.coli.With the increase of ZnO,ZnO/BG scaffolds have better in vitro antibacterial properties.