Study On Na, Mg, Zn And Ti Doped 58S Bioactive Glasses And Glass-ceramics

Bioactive glasses have been widely studied for its bone regeneration ability. Sol-gel bioactive glasses have many advantages comparing to melt derived bioactive glasses. Firstly, sol-gel bioactive glasses have higher bioactivity and degradation rate as compared with melt bioactive glasses with the same composition. Secondly, the properties of the sol-gel bioactive glasses can be easily controlled by modifying the chemical composition and preparing parameters, which make it possible to design bioactive glasses according to different needs. In this work, Na₂O, MgO, ZnO and TiO₂ were introduced into bioactive glasses by substitution of CaO in 58S to modify the chemical composition and properties. In addition, the use of bioactive glasses and glasses-ceramics in porous scaffolds for tissue engineering had also been studied.The results obtained are described as follows:(1) The properties of bioactive glasses are dependent on its Si-O network. The introduced elements affect the properties of the glasses by modifying the Si-O network. In this work, Na₂O is found to be a more effective network disrupting species than CaO. The substitution of CaO by Na₂O decrease the integrity of the Si-O network, and result in a higher ion release rate and higher bioactivity of Na₂O-containing glass as compared with 58S. The substitution of CaO by MgO and ZnO do not affect the integrity of the Si-O network, but make the network much denser. The introducing of MgO and ZnO in 58S causes a decrease of degradation and HA deposition rate of the glasses. Furthermore, ZnO show a more effective effect than...