Research On The Cu-promoted Decarboxylative Cyanation Of Aryl Carboxylic Acids Under Aerobic Conditions

Aryl nitriles are are significant structure fragments found in chemical industry products and natural products,in addition,aryl nitriles are versatile synthetic intermediates that can be facilely converted into a wide variety of functional groups in organic synthesis,including amine,amide,aldehyde,tetrazole and others.The incorporation of cyano group into the structure of drug molecules can remarkably change their properties,including physical and chemical performances.As a result,the synthesis of aryl nitriles is a hot research project in organic synthetic chemistry at present.Carboxylic acids are cheap,non-toxic,stable and easily available compounds.The reaction site of decarboxylation is fixed,and non-toxic carbon dioxide is released as the by-product during decarboxylation.Thus,we'd like to develop cheap copper promoted decarboxylative cyanation of aryl carboxylic acid with green and safe cyan source.The main research contents of the thesis include copper promoted decarboxylative cyanation of aryl carboxylic acid with AMBN or malononitrile as single cyanide source under aerobic conditions,and Ag/Cu bimetallic mediated decarboxylative cyanation of aryl carboxylic acid with the combination of DMF/NH₄OAc as cyanide source.