Highly Sensitive Detection Of Paracetamol Based On Cu Metal-organic Framework

As a result of the development strategy of“Treatment after Pollution”,environmental problems in various aspects have become more prominent in recent years.High performance liquid chromatography,gas chromatography,capillary electrophoresis and fluorescence analysis are often used for the analysis of environmental organic pollutants in water.These methods often require complicated pre-processing and require high technical requirements for instrument operation.Electrochemical sensor detection method has great potential for development because of its sensitive,rapid and accurate characteristics.Paracetamol is a kind of chronic endocrine disrupting substance.It is a kind of environmental organic pollutant which is complicated in structure,difficult to degrade and easy to accumulate.Because of the huge harm to reproductive system,it is very important to study the detection method.In this paper,based on the excellent catalytic properties and large specific surface area of Cu-MOF,in organometallic framework materials?MOFs?,nanometre-recovery materials will be synthesized with gold nanometre particles with unique electrical conductivity,optical and catalytic properties.Using the synthesized materials as electrochemical sensing materials,a novel nanometre composite electrochemical sensor will be constructed,and a set of analytical methods of paracetamol with high sensitivity and low detection limit will be established.The main research contents and results show that:?1?Blue Cu-MOF powder was synthesized by hydrothermal solvent method.The results of scanning microscope and transmission electron microscope show that the crystal is a three-dimensional structure,and the particle size is about 500nm.X-ray powder diffraction crystallization results show that the crystallinity of the prepared Cu-MOF crystal is very high and the structure is stable.?2?In this paper,Cu-MOF/AuNPs nanometre composites were synthesized from AuNPs and Cu-MOF were prepared before.The results of TEM of AuNPs and Cu-MOF/AuNPs show that circular AuNPs has been successfully prepared.Its particle size is 16±1nm,and loaded evenly on Cu-MOF,thus the Cu-MOF/AuNPs nanometre composites are prepared successfully.The UV-vis adsorption spectra further confirmed the successful preparation of the two materials.In this composite,Cu-MOF and AuNPs interact with each other.After comparing the electrochemical signal amplification abilities of Cu-MOF,AuNPs and Cu-MOF/AuNPs nanometre composites,the results showed that the current intensities of AuNPs?Cu-MOF and Cu-MOF/AuNPs were 20?A?45?A and 82?A.The signal strength of nanometre composites is the strongest.When Cu-MOF and AuNPs are combined as a signal amplifier,the peak current of the sensor increases greatly,and the signal intensity increases by 26%compared with the sum of the current intensity of Cu-MOF and AuNPs.?3?The pH value,load and bioconcentration time of the detection condition were optimized by differential pulses voltammetry?DPV?.Finally,the pH value is 6.0,the load is 10?L,the bioconcentration time is 90s for the best detection condition.The influenceofscanning speed on the detection of paracetamol peak current by Cu-MOF/AuNP GCE was further investigated.The results show that the electrochemical reaction process is a quasi-reversible process controlled by adsorption.The calculated number of proton transfer is 1 and the number of electron shifts is 2.The Cu-MOF/AuNPs GCE prepared under the optimum conditions has satisfactory re-producibility,stability and anti-interference for the detection of paracetamol.In the range of concentration from 0.001 to 100?mol/L,there is a good linear relationship between the oxidation peak currents.The linear equation is as follows:I_pa??A?=11.33logc+154.18?R=0.9983?.When LOD=3?/S,LOD is 0.0011 nmol L^-1.Compared with other studies,its electrochemical sensor has high sensitivity,wide detection range and lower detection limit for paracetamol.In addition,Cu-MOF/AuNP GCE can be used for the determination of paracetamol in practical drug samples with a recovery rate of 101.4%¹02.9%.