Multicomponent Synthesis Of Quinoline Compounds And Its Application In Iron Recognition

Ferric ion fluorescence probes have been a hot topic in ion recognition and biosensors.However,due to their high spin state,most of them are fluorescence quenched.Therefore,to overcome the quenching effect of iron and obtain fluorescence-enhanced probes have always been a challenging subject in the field.In this work,quinolines were synthesized from aniline,aldehydes and Alkynes by multi-component reaction.The research contents were summarized as follows:1.Synthesis and characterization of 2,4-substituded quinolines;2.The reaction mechanism was proved by NMR and experiments,and according to the reaction mechanism,the reasons for the reduction of the yield were reasonably explained by using different aldehydes;3.Using 2-pyridyl-4-phenylquinoline as probe,the composition and content of iron ions were detected in solution.The fluorescence data showed that the Fe²⁺complex induced fluorescence quenching,while Fe³⁺complex exhibited fluorescence enhanced;4.According to the relationship between the fluorescence intensity of the probe and different proportions of iron ions,the determination of the composition and content of mixed iron ions was realized in solution;5.The regulation of the fluorescence of iron complexes under different voltage was realized by using electrochemistry and fluorescence spectrometer,the design and research of light switch sensors were achieved successfully.In this paper,a novel molecular fluorescence probe was synthesized and characterized.The iron ions were effectively identified and distinguished.The charge transfer mechanism and fluorescence sensing mechanism after complexing of iron ions were determined by electrochemical data and other experimental data too.Finally,the"on"and"off"of chemiluminescence were realized.These complexes may have potential applications in biochemical sensors of iron ions and erasable electronic information recording devices.