Design And Synthesis Of Polymerizable Amino Acid Molecules And Their Applications In Preparing Porous Polymer Microspheres

Amino acids are organic compounds widely found in nature.They are inexpensive and easy to obtain.Meanwhile,the abundant functional groups on the side chain of amino acids can participate in various enzyme catalytic reactions.Arginine,proline and some polyamino acids have already been widely applied in various fields including asymmetric catalysis and acid-base catalysis.However,current researches on the catalytic process of amino acids are mainly limited to the homogeneous catalysis,in which the high energy consumption and heavy pollution caused by the subsequent separation of the catalysts have always been a key issue to be solved.Inspired by the macroporous catalytic resin microspheres,we designed and synthesized several amino acid monomer molecules with polymerizable groups.Using inorganic macroporous microspheres as a template,we prepared macroporous polymer microspheres with amino acid groups by polymerizing the monomers in the channels of the inorganic microspheres,and studied their morphology and catalytic properties.The main research results are listed as follows:1.A series of fragment molecules with arginine and proline groups and final polymerizable monomers were synthesized.We studied the specific technical route of the synthesis of these compounds.Then Silica microspheres with macroporous structure were prepared and used as the template to prepare macroporous polymer microspheres with amino acid group modifications.It was showed from the experiments that these polymer microspheres exhibited good spherical morphology and pore structure through selecting appropriate inorganic templates and polymerization systems.2.The structure of the microspheres was analyzed by means of electron microscopy and the catalytic effect of the microspheres as a basic catalyst was investigated by Knoevenagel reaction as a probe reaction.The experimental results indicate that the arginine-modified porous microspheres can show a good catalytic effect on this reaction,and the yield can reach over 90% in the weakly polar non-alkaline solvent.3.The monofunctionalization of symmetric bifunctional compounds was discussed by means of numerical calculation,and the corresponding mathematical model was established.This model has certain universality and can provide beneficial references for various molecular design and synthesis.