Analysis Of Relative Species In Neurodegenerative Diseases Based On Fluorescence Lifetime Imaging

With the development of medical science research,medical treatment and diagnostic technology has made great progress,which had great potential of improving quality of human life.However,medical science research is still in the preliminary stage of development,due to the limitations of instruments and the complexity of organisms.The various therapeutic diagnostic drugs and molecules have not been able to achieve accurate targeted tracking and imaging in vivo.Nanomaterials have attracted more and more attention due to their good biocompatibility,low toxicity,strong modifiability and the ability to achieve specific recognition.Neurodegenerative diseases are a kind of disease that cause by loss of neurons structure and function,which seriously affect human health and life.Because of the complexity of the brain and the individual differences of organisms,it is still a challenging subject to analyze the pathogenesis of neurodegenerative diseases at the molecular level.In this paper,the ions and proteins related to neurodegenerative diseases were studied.The following two aspects of work have been carried out.In this paper,a composite nanomaterial was designed and synthesized.The interaction between?-synuclein and iron ions in Parkinson's disease neurons was first analyzed,and the treatment of?-synuclein aggregates was completed.It has found that the increasing of Fe³⁺concentration lead to the aggregation of?-synuclein,while the increasing of?-synuclein fibrils lead to the increasing of Fe³⁺concentration in turn.In addition,an integrated research platform for the therapeutic diagnosis of?-synuclein aggregates was developed by using the photothermal properties of the probe.Based on the previous research,polymer nanomaterials were developed to study the relationship between Zn²⁺and S100-?protein in Alzheimer's disease neurons.Polymer nanomaterials have higher water-solubility and biodegradability,lower biotoxicity and better biological significance,which play a certain role in further promoting clinical research.