Study On Preparation And Biocompatibility Of Polyetheretherketone Composites

Polyetheretherketone(PEEK)is a semi-crystalline thermoplastic engineering plastic with mechanical properties that match the human bone.Its biocompatibility,environmental resistance,abrasion resistance,fatigue resistance and other advantages make it a new generation of orthopedic implant materials.However,biological inertia limits its further application.Hydroxyapatite(HA/HAP)is an important inorganic mineral component in human body's natural bone,which has good bone conductivity and biocompatibility,but its poor mechanical properties make it unsuitable to be implanted into human body as a structural material alone.Hydroxyapatite(HAP)/polyetherketone(PEEK)composite is a new generation of bone implant material widely used at present.Combined with the advantages of the two components,it has good biocompatibility while satisfying the compatibility of human mechanical properties,that is,it is connected with human bone.The biocompatibility of hydroxyapatite/polyetheretherketone composites was further improved from two aspects.Firstly,the weak magnetic field can improve the biocompatibility of composites.In this paper,FeNi alloy nanometer powder and FeNi/HAP/PEEK composite were prepared by liquid phase chemical reduction and liquid phase mixing.The FeNi alloy nanometer powder was prepared with a particle size of 100nm and good chemical activity and magnetic properties.The saturation magnetization of FeNi alloy powder was 70emu/g.In the FeNi/HAP/PEEK composite material,the FeNi nanometer powder was uniformly distributed in the matrix in the form of a single particle,which reached the level of nanometer dispersion.With the increase of FeNi alloy powder content,the magnetic properties of the composites were significantly enhanced.The biocompatibility of FeNi/HAP/PEEK composite was significantly better than that of PEEK and HAP/PEEK.The 2%FeNi/HAP/PEEK composite has the optimal comprehensive performance,with good biocompatibility,saturation magnetization(Ms)up to 1.5emu/g and hardness up to 42HBa.Secondly,the biocompatibility of composites was improved by using bioactive metals.Among the metal materials,tantalum and titanium are the most widely used bone implant materials,but their application is limited by the disadvantages of stress shielding,poor wettability and weak bone connection ability.In this paper,tantalum and titanium were compounded into HAP/PEEK composites at 3%and 5%content,respectively,to study their mechanical properties and biological functional properties.Compared with tantalum,the composite material with titanium added had lower young's modulus,higher hardness and better wettability.The young's modulus of 5%Ti/HAP/PEEK was 815MPa,the contact Angle was 48.44° and the hardness was 45.5HBa.The highest hardness of Ti/HAP/PEEK was 56.88.In the in vitro biocompatibility experiment,all the four materials showed good bone connection performance.Apatite on the surface of 5%Ti/HAP/PEEK had the largest area and the fastest growth,and it also had the effect of promoting the proliferation of human osteosarcoma mg-63 cells.PEEK composites containing tantalum and titanium have better mechanical properties and biocompatibility.The results showed that on the basis of hydroxyapatite/polyether ether ketone composite,the biocompatibility of PEEK composite was enhanced by weak magnetic field and bioactive metal.The results showed that on the basis of hydroxyapatite/PEEK composite,the biocompatibility of PEEK composite was enhanced by weak magnetic field and bioactive metal.The results of cytotoxic experiment and in vitro simulated body fluid immersion experiment showed that weak magnetic field and bioactive metals could promote the osteogenic differentiation and the ability of bone guidance.